Recovery of the maternal skeleton after lactation is impaired by advanced maternal age but not by reduced IGF availability in the mouse

Background Lactation results in substantial maternal bone loss that is recovered following weaning. However, the mechanisms underlying this recovery, and in particular the role of insulin-like growth factor 1 (IGF-I), is not clear. Furthermore, there is little data regarding whether recovery is affe...

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Veröffentlicht in:	PloS one 2021-09, Vol.16 (9), p.e0256906-e0256906, Article 0256906
Hauptverfasser:	Rogowska, Monika D., Pena, Uriel N., Binning, Nimrat, Christians, Julian K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Availability Biology and Life Sciences Bone density Bone loss Breast feeding Breastfeeding & lactation Cancellous bone Computed tomography Cortical bone Data recovery Gene deletion Growth factors Health aspects Insulin Insulin-like growth factor 1 Insulin-like growth factor I Insulin-like growth factor-binding protein 5 Insulin-like growth factors Lactation Long-term effects Medicine and Health Sciences Menopause Mice Multidisciplinary Sciences Physical Sciences Pregnancy Pregnant women R&D Recovery (Medical) Research & development Research and Analysis Methods Science & Technology Science & Technology - Other Topics Skeleton Social Sciences Weaning
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