Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene

BackgroundSinonasal Undifferentiated Carcinoma (SNUC) is a rare and aggressive skull base tumor with poor survival and limited treatment options. To date, targeted sequencing studies have identified IDH2 and SMARCB1 as potential driver alterations, but the molecular alterations found in SMARCB1 wild...

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Veröffentlicht in:	BMC cancer 2021-05, Vol.21 (1), p.1-636, Article 636
Hauptverfasser:	Neal, Molly E. Heft, Birkeland, Andrew C., Bhangale, Apurva D., Zhai, Jingyi, Kulkarni, Aditi, Foltin, Susan K., Jewell, Brittany M., Ludwig, Megan L., Pinatti, Lisa, Jiang, Hui, McHugh, Jonathan B., Marentette, Lawence, McKean, Erin L., Brenner, J. Chad
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase Biomarkers Cancer Cell fusion Chemotherapy Copy number Development and progression E2F protein Fusion protein Gene fusion Gene mutations Genetic analysis Genetic aspects Genomes Life Sciences & Biomedicine Medical prognosis Microsatellite instability Mutation Myc protein Nose cancer Oncology Oncology, Experimental Pathogenesis Patients Radiation Science & Technology siRNA SMARCA SNUC Software Surgery Survival analysis SWI/SNF Tumors
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