Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up
Objective: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that...
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| Veröffentlicht in: | Oncology 2017-01, Vol.93 (2), p.106-114 |
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| creator | Obrzut, Bogdan Semczuk, Andrzej Naróg, Maciej Obrzut, Marzanna Król, Piotr |
| description | Objective: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed. Results: Univariate analysis revealed that only lymphovascular space invasion significantly affected 10-year overall survival (p = 0.04), but it had no effect on the 10-year disease-free survival rate. Multivariate analysis demonstrated that survival rates were significantly affected by FIGO stage (p = 0.02, 95% CI: 1.18-5.55, for 10-year overall survival; p = 0.03, 95% CI: 1.07-6.12, for 10-year disease-free survival) and metastases to the pelvic lymph nodes (p = 0.0005, 95% CI: 1.81-8.53, for 10-year overall survival; p = 0.01, 95% CI: 1.26-7.24, for 10-year disease-free survival). Conclusions: The only independent prognostic factors for 10-year survival rates in patients with cervical cancer at FIGO stages IA2-IIB were clinical stage and presence of metastases to the pelvic lymph nodes. The presence of lymphovascular space invasion adversely affected 10-year overall survival. |
| doi_str_mv | 10.1159/000471766 |
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Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed. Results: Univariate analysis revealed that only lymphovascular space invasion significantly affected 10-year overall survival (p = 0.04), but it had no effect on the 10-year disease-free survival rate. Multivariate analysis demonstrated that survival rates were significantly affected by FIGO stage (p = 0.02, 95% CI: 1.18-5.55, for 10-year overall survival; p = 0.03, 95% CI: 1.07-6.12, for 10-year disease-free survival) and metastases to the pelvic lymph nodes (p = 0.0005, 95% CI: 1.81-8.53, for 10-year overall survival; p = 0.01, 95% CI: 1.26-7.24, for 10-year disease-free survival). Conclusions: The only independent prognostic factors for 10-year survival rates in patients with cervical cancer at FIGO stages IA2-IIB were clinical stage and presence of metastases to the pelvic lymph nodes. The presence of lymphovascular space invasion adversely affected 10-year overall survival.</description><identifier>ISSN: 0030-2414</identifier><identifier>EISSN: 1423-0232</identifier><identifier>DOI: 10.1159/000471766</identifier><identifier>PMID: 28463843</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adenocarcinoma - diagnosis ; Adenocarcinoma - pathology ; Adenocarcinoma - therapy ; Adult ; Aged ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - pathology ; Carcinoma, Squamous Cell - therapy ; Care and treatment ; Cervical cancer ; Clinical Study ; Development and progression ; Disease-Free Survival ; Evaluation ; Female ; Follow-Up Studies ; Humans ; Hysterectomy ; Lymph Node Excision ; Medical societies ; Middle Aged ; Neoplasm Staging ; Poland ; Prognosis ; Prospective Studies ; Survival Analysis ; Treatment Outcome ; Uterine Cervical Neoplasms - diagnosis ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - therapy ; Women's Health</subject><ispartof>Oncology, 2017-01, Vol.93 (2), p.106-114</ispartof><rights>2017 S. Karger AG, Basel</rights><rights>2017 S. Karger AG, Basel.</rights><rights>COPYRIGHT 2017 S. Karger AG</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c337t-73a0de3400256080efcc24d5fe23b9e018395d60ca59d8d6f49da06660c0adb13</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2422,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28463843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Obrzut, Bogdan</creatorcontrib><creatorcontrib>Semczuk, Andrzej</creatorcontrib><creatorcontrib>Naróg, Maciej</creatorcontrib><creatorcontrib>Obrzut, Marzanna</creatorcontrib><creatorcontrib>Król, Piotr</creatorcontrib><title>Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up</title><title>Oncology</title><addtitle>Oncology</addtitle><description>Objective: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed. Results: Univariate analysis revealed that only lymphovascular space invasion significantly affected 10-year overall survival (p = 0.04), but it had no effect on the 10-year disease-free survival rate. Multivariate analysis demonstrated that survival rates were significantly affected by FIGO stage (p = 0.02, 95% CI: 1.18-5.55, for 10-year overall survival; p = 0.03, 95% CI: 1.07-6.12, for 10-year disease-free survival) and metastases to the pelvic lymph nodes (p = 0.0005, 95% CI: 1.81-8.53, for 10-year overall survival; p = 0.01, 95% CI: 1.26-7.24, for 10-year disease-free survival). Conclusions: The only independent prognostic factors for 10-year survival rates in patients with cervical cancer at FIGO stages IA2-IIB were clinical stage and presence of metastases to the pelvic lymph nodes. The presence of lymphovascular space invasion adversely affected 10-year overall survival.</description><subject>Adenocarcinoma - diagnosis</subject><subject>Adenocarcinoma - pathology</subject><subject>Adenocarcinoma - therapy</subject><subject>Adult</subject><subject>Aged</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Carcinoma, Squamous Cell - therapy</subject><subject>Care and treatment</subject><subject>Cervical cancer</subject><subject>Clinical Study</subject><subject>Development and progression</subject><subject>Disease-Free Survival</subject><subject>Evaluation</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Hysterectomy</subject><subject>Lymph Node Excision</subject><subject>Medical societies</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Poland</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Survival Analysis</subject><subject>Treatment Outcome</subject><subject>Uterine Cervical Neoplasms - diagnosis</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - therapy</subject><subject>Women's Health</subject><issn>0030-2414</issn><issn>1423-0232</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90N9r2zAQB3AxOta028PeR9HTaB-8nX5YtvaWhaYzBFpY-2wU-ey4la1UUlb6388laZ6OOz53B19CvjL4wViufwKALFih1AcyY5KLDLjgJ2QGICDjkslTchbj48SKXKpP5JSXUolSihlZ3wXfjT6m3tI7E8yACUOkrQ9Tm3ocU6QvfdrQBYZ_vTWOLsxoMdBldXNL_ybTYaTVnGdV9fsXndOVH7vsHsNAl945_5I9bD-Tj61xEb8c6jl5WF7fL_5kq9ubajFfZVaIImWFMNCgkAA8V1ACttZy2eQtcrHWCKwUOm8UWJPrpmxUK3VjQKlpAqZZM3FOLvd3t8E_7zCmeuijRefMiH4Xa1Zqqd9SEhP9vqedcVhv0Li0id7tUu_HWM-VKITWwNUEr_bQBh9jwLbehn4w4bVmUL9lXx-zn-zF4f9uPWBzlO9hT-DbHjyZ0GE4gsP-f9HvhEg</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Obrzut, Bogdan</creator><creator>Semczuk, Andrzej</creator><creator>Naróg, Maciej</creator><creator>Obrzut, Marzanna</creator><creator>Król, Piotr</creator><general>S. Karger AG</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20170101</creationdate><title>Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up</title><author>Obrzut, Bogdan ; Semczuk, Andrzej ; Naróg, Maciej ; Obrzut, Marzanna ; Król, Piotr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c337t-73a0de3400256080efcc24d5fe23b9e018395d60ca59d8d6f49da06660c0adb13</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adenocarcinoma - diagnosis</topic><topic>Adenocarcinoma - pathology</topic><topic>Adenocarcinoma - therapy</topic><topic>Adult</topic><topic>Aged</topic><topic>Carcinoma, Squamous Cell - diagnosis</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Carcinoma, Squamous Cell - therapy</topic><topic>Care and treatment</topic><topic>Cervical cancer</topic><topic>Clinical Study</topic><topic>Development and progression</topic><topic>Disease-Free Survival</topic><topic>Evaluation</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Hysterectomy</topic><topic>Lymph Node Excision</topic><topic>Medical societies</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Poland</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Survival Analysis</topic><topic>Treatment Outcome</topic><topic>Uterine Cervical Neoplasms - diagnosis</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - therapy</topic><topic>Women's Health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Obrzut, Bogdan</creatorcontrib><creatorcontrib>Semczuk, Andrzej</creatorcontrib><creatorcontrib>Naróg, Maciej</creatorcontrib><creatorcontrib>Obrzut, Marzanna</creatorcontrib><creatorcontrib>Król, Piotr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Obrzut, Bogdan</au><au>Semczuk, Andrzej</au><au>Naróg, Maciej</au><au>Obrzut, Marzanna</au><au>Król, Piotr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up</atitle><jtitle>Oncology</jtitle><addtitle>Oncology</addtitle><date>2017-01-01</date><risdate>2017</risdate><volume>93</volume><issue>2</issue><spage>106</spage><epage>114</epage><pages>106-114</pages><issn>0030-2414</issn><eissn>1423-0232</eissn><abstract>Objective: We assessed the prognostic factors related to 10-year overall survival and disease-free survival in cervical cancer patients that underwent primary surgical protocols in 1 institution. Materials and Methods: A total of 102 patients with uterine cervical cancer at FIGO stages IA2-IIB that underwent a Piver type III radical hysterectomy and pelvic lymphadenectomy between 1998 and 2001 were included. Univariate and multivariate analyses of 10-year overall survival and 10-year disease-free survival were performed. Results: Univariate analysis revealed that only lymphovascular space invasion significantly affected 10-year overall survival (p = 0.04), but it had no effect on the 10-year disease-free survival rate. Multivariate analysis demonstrated that survival rates were significantly affected by FIGO stage (p = 0.02, 95% CI: 1.18-5.55, for 10-year overall survival; p = 0.03, 95% CI: 1.07-6.12, for 10-year disease-free survival) and metastases to the pelvic lymph nodes (p = 0.0005, 95% CI: 1.81-8.53, for 10-year overall survival; p = 0.01, 95% CI: 1.26-7.24, for 10-year disease-free survival). Conclusions: The only independent prognostic factors for 10-year survival rates in patients with cervical cancer at FIGO stages IA2-IIB were clinical stage and presence of metastases to the pelvic lymph nodes. The presence of lymphovascular space invasion adversely affected 10-year overall survival.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>28463843</pmid><doi>10.1159/000471766</doi><tpages>9</tpages></addata></record> |
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| subjects | Adenocarcinoma - diagnosis Adenocarcinoma - pathology Adenocarcinoma - therapy Adult Aged Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - pathology Carcinoma, Squamous Cell - therapy Care and treatment Cervical cancer Clinical Study Development and progression Disease-Free Survival Evaluation Female Follow-Up Studies Humans Hysterectomy Lymph Node Excision Medical societies Middle Aged Neoplasm Staging Poland Prognosis Prospective Studies Survival Analysis Treatment Outcome Uterine Cervical Neoplasms - diagnosis Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - therapy Women's Health |
| title | Prognostic Parameters for Patients with Cervical Cancer FIGO Stages IA2-IIB: A Long-Term Follow-Up |
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