The reasons to include the serology of human T-lymphotropic virus types 1 and 2

The reasons to include the serology of human T-lymphotropic virus types 1 and 2

Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:PLoS neglected tropical diseases 2020-05, Vol.14 (5)
Hauptverfasser: Caterino-de-Araujo, Adele, Moreira, Regina Célia, Campos, Karoline Rodrigues, Alves, Fabiana Aparecida, Marcusso, Rosa Maria Nascimento, Lemos, Marcílio Figueiredo
Format: Artikel
Sprache:eng
Schlagworte:
Care and treatment
Complications and side effects
Diagnosis
Hepatitis B
Hepatitis C
HTLV-I infections
HTLV-II infections
Prognosis
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 5
container_start_page
container_title PLoS neglected tropical diseases
container_volume 14
creator Caterino-de-Araujo, Adele
Moreira, Regina Célia
Campos, Karoline Rodrigues
Alves, Fabiana Aparecida
Marcusso, Rosa Maria Nascimento
Lemos, Marcílio Figueiredo
description Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology This study aimed to add information concerning the influence of human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) infections in hepatitis B and C, since in Brazil, these human retroviruses are endemic but neglected. Serum samples from 1,910 patients with hepatitis B and 1,315 with hepatitis C from São Paulo, southeast Brazil, that were previously tested and grouped for HIV and HTLV-1/-2 coinfections were analyzed for hepatitis B virus (HBV) and hepatitis C virus (HCV) loads measurements and subsequent clearance using data from laboratory records. Key results Briefly, the lowest HBV viral load (VL) was detected in HBV/HTLV-2 coinfected patients, regardless of whether they were infected with HIV (all comparisons p
format Article
fullrecord <record><control><sourceid>gale</sourceid><recordid>TN_cdi_gale_healthsolutions_A632951985</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A632951985</galeid><sourcerecordid>A632951985</sourcerecordid><originalsourceid>FETCH-gale_healthsolutions_A6329519853</originalsourceid><addsrcrecordid>eNqNjbsKwjAYRjMoWC_v8E9uhSYlthlFFDeX7iW0aRNJ85dchL69HXwApw8O5_BtSEZFyXNWsWpH9iG8i4ILXtOMvBqtwCsZ0AWICMZ1NvUK4oqD8mhxXAAH0GmSDprcLtOsMXqcTQcf49NaLbMKQEG6HtiRbAdpgzr99kDOj3tze-ajtKrVStqoA9oUzXrYXi8lE5yKmpd_i1_8hj_F</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>The reasons to include the serology of human T-lymphotropic virus types 1 and 2</title><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>Public Library of Science (PLoS) Journals Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Caterino-de-Araujo, Adele ; Moreira, Regina Célia ; Campos, Karoline Rodrigues ; Alves, Fabiana Aparecida ; Marcusso, Rosa Maria Nascimento ; Lemos, Marcílio Figueiredo</creator><creatorcontrib>Caterino-de-Araujo, Adele ; Moreira, Regina Célia ; Campos, Karoline Rodrigues ; Alves, Fabiana Aparecida ; Marcusso, Rosa Maria Nascimento ; Lemos, Marcílio Figueiredo</creatorcontrib><description>Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology This study aimed to add information concerning the influence of human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) infections in hepatitis B and C, since in Brazil, these human retroviruses are endemic but neglected. Serum samples from 1,910 patients with hepatitis B and 1,315 with hepatitis C from São Paulo, southeast Brazil, that were previously tested and grouped for HIV and HTLV-1/-2 coinfections were analyzed for hepatitis B virus (HBV) and hepatitis C virus (HCV) loads measurements and subsequent clearance using data from laboratory records. Key results Briefly, the lowest HBV viral load (VL) was detected in HBV/HTLV-2 coinfected patients, regardless of whether they were infected with HIV (all comparisons p&lt;0.05). In contrast, higher HCV VL was detected in HCV/HIV, HCV/HIV/HTLV-1/-2 coinfected patients (all p&lt;0.05), and the lowest HCV VL was detected in HCV/HTLV-2 coinfected patients. Curiously, 61.1% of the patients with HBV/HTLV-2 coinfection had an undetectable HBV VL at the beginning of the study versus 21.4% in the patients with HBV/HTLV-1 coinfection. Although the percentages of undetectable HCV loads in HCV/HTLV-1 and HCV/HTLV-2 coinfected patients were quite similar, during follow-up, more HCV clearance was detected in patients with HCV/HTLV-2 coinfection [OR 2.65; 95% IC (1.17-5.99)]. Major conclusions HTLV-2 positively impacts HBV and HCV viral loads and HCV clearance, while HIV and/or HTLV-1 negatively impacts HCV viral load. Thus, the search for HTLV-1/-2 in viral hepatitis B and C infected patients has virological prognostic value, which is a strong reason to suggest including HTLV serology in the follow-up of patients.</description><identifier>ISSN: 1935-2727</identifier><language>eng</language><publisher>Public Library of Science</publisher><subject>Care and treatment ; Complications and side effects ; Diagnosis ; Hepatitis B ; Hepatitis C ; HTLV-I infections ; HTLV-II infections ; Prognosis</subject><ispartof>PLoS neglected tropical diseases, 2020-05, Vol.14 (5)</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Caterino-de-Araujo, Adele</creatorcontrib><creatorcontrib>Moreira, Regina Célia</creatorcontrib><creatorcontrib>Campos, Karoline Rodrigues</creatorcontrib><creatorcontrib>Alves, Fabiana Aparecida</creatorcontrib><creatorcontrib>Marcusso, Rosa Maria Nascimento</creatorcontrib><creatorcontrib>Lemos, Marcílio Figueiredo</creatorcontrib><title>The reasons to include the serology of human T-lymphotropic virus types 1 and 2</title><title>PLoS neglected tropical diseases</title><description>Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology This study aimed to add information concerning the influence of human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) infections in hepatitis B and C, since in Brazil, these human retroviruses are endemic but neglected. Serum samples from 1,910 patients with hepatitis B and 1,315 with hepatitis C from São Paulo, southeast Brazil, that were previously tested and grouped for HIV and HTLV-1/-2 coinfections were analyzed for hepatitis B virus (HBV) and hepatitis C virus (HCV) loads measurements and subsequent clearance using data from laboratory records. Key results Briefly, the lowest HBV viral load (VL) was detected in HBV/HTLV-2 coinfected patients, regardless of whether they were infected with HIV (all comparisons p&lt;0.05). In contrast, higher HCV VL was detected in HCV/HIV, HCV/HIV/HTLV-1/-2 coinfected patients (all p&lt;0.05), and the lowest HCV VL was detected in HCV/HTLV-2 coinfected patients. Curiously, 61.1% of the patients with HBV/HTLV-2 coinfection had an undetectable HBV VL at the beginning of the study versus 21.4% in the patients with HBV/HTLV-1 coinfection. Although the percentages of undetectable HCV loads in HCV/HTLV-1 and HCV/HTLV-2 coinfected patients were quite similar, during follow-up, more HCV clearance was detected in patients with HCV/HTLV-2 coinfection [OR 2.65; 95% IC (1.17-5.99)]. Major conclusions HTLV-2 positively impacts HBV and HCV viral loads and HCV clearance, while HIV and/or HTLV-1 negatively impacts HCV viral load. Thus, the search for HTLV-1/-2 in viral hepatitis B and C infected patients has virological prognostic value, which is a strong reason to suggest including HTLV serology in the follow-up of patients.</description><subject>Care and treatment</subject><subject>Complications and side effects</subject><subject>Diagnosis</subject><subject>Hepatitis B</subject><subject>Hepatitis C</subject><subject>HTLV-I infections</subject><subject>HTLV-II infections</subject><subject>Prognosis</subject><issn>1935-2727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqNjbsKwjAYRjMoWC_v8E9uhSYlthlFFDeX7iW0aRNJ85dchL69HXwApw8O5_BtSEZFyXNWsWpH9iG8i4ILXtOMvBqtwCsZ0AWICMZ1NvUK4oqD8mhxXAAH0GmSDprcLtOsMXqcTQcf49NaLbMKQEG6HtiRbAdpgzr99kDOj3tze-ajtKrVStqoA9oUzXrYXi8lE5yKmpd_i1_8hj_F</recordid><startdate>20200526</startdate><enddate>20200526</enddate><creator>Caterino-de-Araujo, Adele</creator><creator>Moreira, Regina Célia</creator><creator>Campos, Karoline Rodrigues</creator><creator>Alves, Fabiana Aparecida</creator><creator>Marcusso, Rosa Maria Nascimento</creator><creator>Lemos, Marcílio Figueiredo</creator><general>Public Library of Science</general><scope/></search><sort><creationdate>20200526</creationdate><title>The reasons to include the serology of human T-lymphotropic virus types 1 and 2</title><author>Caterino-de-Araujo, Adele ; Moreira, Regina Célia ; Campos, Karoline Rodrigues ; Alves, Fabiana Aparecida ; Marcusso, Rosa Maria Nascimento ; Lemos, Marcílio Figueiredo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-gale_healthsolutions_A6329519853</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Care and treatment</topic><topic>Complications and side effects</topic><topic>Diagnosis</topic><topic>Hepatitis B</topic><topic>Hepatitis C</topic><topic>HTLV-I infections</topic><topic>HTLV-II infections</topic><topic>Prognosis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Caterino-de-Araujo, Adele</creatorcontrib><creatorcontrib>Moreira, Regina Célia</creatorcontrib><creatorcontrib>Campos, Karoline Rodrigues</creatorcontrib><creatorcontrib>Alves, Fabiana Aparecida</creatorcontrib><creatorcontrib>Marcusso, Rosa Maria Nascimento</creatorcontrib><creatorcontrib>Lemos, Marcílio Figueiredo</creatorcontrib><jtitle>PLoS neglected tropical diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Caterino-de-Araujo, Adele</au><au>Moreira, Regina Célia</au><au>Campos, Karoline Rodrigues</au><au>Alves, Fabiana Aparecida</au><au>Marcusso, Rosa Maria Nascimento</au><au>Lemos, Marcílio Figueiredo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The reasons to include the serology of human T-lymphotropic virus types 1 and 2</atitle><jtitle>PLoS neglected tropical diseases</jtitle><date>2020-05-26</date><risdate>2020</risdate><volume>14</volume><issue>5</issue><issn>1935-2727</issn><abstract>Background The WHO established targets for 2030 to globally reduce new viral hepatitis B and C infections by 90% and deaths by 65% and recommends searching for coinfections that increase the progression of chronic liver infections towards cirrhosis and hepatocellular carcinoma. Aims and methodology This study aimed to add information concerning the influence of human T-lymphotropic virus type 1 (HTLV-1) and type 2 (HTLV-2) infections in hepatitis B and C, since in Brazil, these human retroviruses are endemic but neglected. Serum samples from 1,910 patients with hepatitis B and 1,315 with hepatitis C from São Paulo, southeast Brazil, that were previously tested and grouped for HIV and HTLV-1/-2 coinfections were analyzed for hepatitis B virus (HBV) and hepatitis C virus (HCV) loads measurements and subsequent clearance using data from laboratory records. Key results Briefly, the lowest HBV viral load (VL) was detected in HBV/HTLV-2 coinfected patients, regardless of whether they were infected with HIV (all comparisons p&lt;0.05). In contrast, higher HCV VL was detected in HCV/HIV, HCV/HIV/HTLV-1/-2 coinfected patients (all p&lt;0.05), and the lowest HCV VL was detected in HCV/HTLV-2 coinfected patients. Curiously, 61.1% of the patients with HBV/HTLV-2 coinfection had an undetectable HBV VL at the beginning of the study versus 21.4% in the patients with HBV/HTLV-1 coinfection. Although the percentages of undetectable HCV loads in HCV/HTLV-1 and HCV/HTLV-2 coinfected patients were quite similar, during follow-up, more HCV clearance was detected in patients with HCV/HTLV-2 coinfection [OR 2.65; 95% IC (1.17-5.99)]. Major conclusions HTLV-2 positively impacts HBV and HCV viral loads and HCV clearance, while HIV and/or HTLV-1 negatively impacts HCV viral load. Thus, the search for HTLV-1/-2 in viral hepatitis B and C infected patients has virological prognostic value, which is a strong reason to suggest including HTLV serology in the follow-up of patients.</abstract><pub>Public Library of Science</pub></addata></record>
fulltext fulltext
identifier ISSN: 1935-2727
ispartof PLoS neglected tropical diseases, 2020-05, Vol.14 (5)
issn 1935-2727
language eng
recordid cdi_gale_healthsolutions_A632951985
source DOAJ Directory of Open Access Journals; PubMed Central Open Access; Public Library of Science (PLoS) Journals Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central
subjects Care and treatment
Complications and side effects
Diagnosis
Hepatitis B
Hepatitis C
HTLV-I infections
HTLV-II infections
Prognosis
title The reasons to include the serology of human T-lymphotropic virus types 1 and 2
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-01T23%3A32%3A39IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20reasons%20to%20include%20the%20serology%20of%20human%20T-lymphotropic%20virus%20types%201%20and%202&rft.jtitle=PLoS%20neglected%20tropical%20diseases&rft.au=Caterino-de-Araujo,%20Adele&rft.date=2020-05-26&rft.volume=14&rft.issue=5&rft.issn=1935-2727&rft_id=info:doi/&rft_dat=%3Cgale%3EA632951985%3C/gale%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rft_galeid=A632951985&rfr_iscdi=true