Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma
Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⺠T-cell...
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| creator | Koike, Kazushige Dehari, Hironari Ogi, Kazuhiro Shimizu, Shota Nishiyama, Koyo Sonoda, Tomoko Sasaki, Takanori Sasaya, Takashi Tsuchihashi, Kei Hasegawa, Tadashi Torigoe, Toshihiko Hiratsuka, Hiroyoshi Miyazaki, Akihiro |
| description | Tumor-infiltrating lymphocytes include tumor-reactive lymphocytes and regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⺠T-cells and CTLA-4⺠cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3⺠T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4⺠cells in the parenchyma of the invasive front. The presence of FoxP3⺠T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3⺠T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4.sup.+ cells suppress the function of FoxP3.sup.+ T-cells and promote anti-tumor immunity in OSCC. |
| doi_str_mv | 10.1371/journal.pone.0237465 |
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However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⺠T-cells and CTLA-4⺠cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3⺠T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4⺠cells in the parenchyma of the invasive front. The presence of FoxP3⺠T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3⺠T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4.sup.+ cells suppress the function of FoxP3.sup.+ T-cells and promote anti-tumor immunity in OSCC.</description><identifier>ISSN: 1932-6203</identifier><identifier>EISSN: 1932-6203</identifier><identifier>DOI: 10.1371/journal.pone.0237465</identifier><identifier>PMID: 32785290</identifier><language>eng</language><publisher>San Francisco: Public Library of Science</publisher><subject>Antibodies ; Anticancer properties ; Biology and Life Sciences ; Cancer therapies ; Cell survival ; Chemotherapy ; CTLA-4 protein ; Foxp3 protein ; Genetic aspects ; Head & neck cancer ; Health aspects ; Immunoglobulins ; Immunohistochemistry ; Invasiveness ; Lymphocytes ; Lymphocytes T ; Medical prognosis ; Medicine ; Medicine and Health Sciences ; Metastases ; Mouth cancer ; Oral cancer ; Oral squamous cell carcinoma ; Parenchyma ; Pathology ; Patients ; Prognosis ; Radiation therapy ; Software ; Squamous cell carcinoma ; Stroma ; Supervision ; Surgery ; Survival ; Transcription factors ; Tumor-infiltrating lymphocytes ; Tumors</subject><ispartof>PloS one, 2020-08, Vol.15 (8), p.e0237465-e0237465</ispartof><rights>COPYRIGHT 2020 Public Library of Science</rights><rights>2020 Koike et al. 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However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⺠T-cells and CTLA-4⺠cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3⺠T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4⺠cells in the parenchyma of the invasive front. The presence of FoxP3⺠T-cells in the parenchyma of the invasive front may be a useful prognostic factor. 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In addition, our results suggest that CTLA-4.sup.+ cells suppress the function of FoxP3.sup.+ T-cells and promote anti-tumor immunity in OSCC.</description><subject>Antibodies</subject><subject>Anticancer properties</subject><subject>Biology and Life Sciences</subject><subject>Cancer therapies</subject><subject>Cell survival</subject><subject>Chemotherapy</subject><subject>CTLA-4 protein</subject><subject>Foxp3 protein</subject><subject>Genetic aspects</subject><subject>Head & neck cancer</subject><subject>Health aspects</subject><subject>Immunoglobulins</subject><subject>Immunohistochemistry</subject><subject>Invasiveness</subject><subject>Lymphocytes</subject><subject>Lymphocytes T</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine and Health Sciences</subject><subject>Metastases</subject><subject>Mouth cancer</subject><subject>Oral cancer</subject><subject>Oral squamous cell 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value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma</title><author>Koike, Kazushige ; Dehari, Hironari ; Ogi, Kazuhiro ; Shimizu, Shota ; Nishiyama, Koyo ; Sonoda, Tomoko ; Sasaki, Takanori ; Sasaya, Takashi ; Tsuchihashi, Kei ; Hasegawa, Tadashi ; Torigoe, Toshihiko ; Hiratsuka, Hiroyoshi ; Miyazaki, Akihiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c669t-94bf09e3d9a0173578b811a640a372bfbbc63c7f515024d84ed808b42c8c9a963</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Antibodies</topic><topic>Anticancer properties</topic><topic>Biology and Life Sciences</topic><topic>Cancer therapies</topic><topic>Cell survival</topic><topic>Chemotherapy</topic><topic>CTLA-4 protein</topic><topic>Foxp3 protein</topic><topic>Genetic aspects</topic><topic>Head & neck cancer</topic><topic>Health 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regulatory T-cells. However, the prognostic value of tumor-infiltrating lymphocytes in oral squamous cell carcinoma (OSCC) remains unclear. We used immunohistochemistry to evaluate the presence of tumor-infiltrating FoxP3⺠T-cells and CTLA-4⺠cells in four distinct histological compartments (tumor parenchyma and stroma at the tumor center, and parenchyma and stroma at the invasive front) and assessed the association between the prevalence of these cells and the histopathological status of 137 patients with OSCC. Five-year overall survival, disease-specific survival, and recurrence-free survival were favorable in patients with high numbers of FoxP3⺠T-cells in the parenchyma of the invasive front. Recurrence-free survival and metastasis-free survival were decreased in patients with high numbers of CTLA-4⺠cells in the parenchyma of the invasive front. The presence of FoxP3⺠T-cells in the parenchyma of the invasive front may be a useful prognostic factor. Our results indicate that FoxP3⺠T-cells may exert site-specific anti-tumor effects but may not play an immunosuppressive role in OSCC. In addition, our results suggest that CTLA-4.sup.+ cells suppress the function of FoxP3.sup.+ T-cells and promote anti-tumor immunity in OSCC.</abstract><cop>San Francisco</cop><pub>Public Library of Science</pub><pmid>32785290</pmid><doi>10.1371/journal.pone.0237465</doi><tpages>e0237465</tpages><orcidid>https://orcid.org/0000-0003-3290-6205</orcidid><orcidid>https://orcid.org/0000-0001-6880-2454</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Public Library of Science (PLoS); EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Antibodies Anticancer properties Biology and Life Sciences Cancer therapies Cell survival Chemotherapy CTLA-4 protein Foxp3 protein Genetic aspects Head & neck cancer Health aspects Immunoglobulins Immunohistochemistry Invasiveness Lymphocytes Lymphocytes T Medical prognosis Medicine Medicine and Health Sciences Metastases Mouth cancer Oral cancer Oral squamous cell carcinoma Parenchyma Pathology Patients Prognosis Radiation therapy Software Squamous cell carcinoma Stroma Supervision Surgery Survival Transcription factors Tumor-infiltrating lymphocytes Tumors |
| title | Prognostic value of FoxP3 and CTLA-4 expression in patients with oral squamous cell carcinoma |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-21T09%3A13%3A20IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_plos_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Prognostic%20value%20of%20FoxP3%20and%20CTLA-4%20expression%20in%20patients%20with%20oral%20squamous%20cell%20carcinoma&rft.jtitle=PloS%20one&rft.au=Koike,%20Kazushige&rft.date=2020-08-12&rft.volume=15&rft.issue=8&rft.spage=e0237465&rft.epage=e0237465&rft.pages=e0237465-e0237465&rft.issn=1932-6203&rft.eissn=1932-6203&rft_id=info:doi/10.1371/journal.pone.0237465&rft_dat=%3Cgale_plos_%3EA632306451%3C/gale_plos_%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2433244092&rft_id=info:pmid/32785290&rft_galeid=A632306451&rft_doaj_id=oai_doaj_org_article_8e353a9de3c242e8ab7829d2bd67e67b&rfr_iscdi=true |