Synthesis and
Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity. Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses....
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| Veröffentlicht in: | Future medicinal chemistry 2018-10, Vol.10 (19), p.2293-2308 |
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| container_title | Future medicinal chemistry |
| container_volume | 10 |
| creator | K adna, Aleksandra Berczy ski, Pawe Dündar, Oya Bozda Ünlüsoy, Meltem Ceylan Sar, Elmas Bakinowska, Bernadetta Kruk, Irena Aboul-Enein, Hassan Y |
| description | Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity.
Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their
antioxidant potency by employing various antioxidant assays.
All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%), 2,2-diphenyl-1-picrylhydrazyl
(17-48%) at 1.25 and 0.5 mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1 μm trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7 μm trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group. |
| doi_str_mv | 10.4155/fmc-2018-0206 |
| format | Article |
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Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their
antioxidant potency by employing various antioxidant assays.
All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%), 2,2-diphenyl-1-picrylhydrazyl
(17-48%) at 1.25 and 0.5 mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1 μm trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7 μm trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.</description><identifier>ISSN: 1756-8919</identifier><identifier>EISSN: 1756-8927</identifier><identifier>DOI: 10.4155/fmc-2018-0206</identifier><language>eng</language><publisher>Future Science Ltd</publisher><subject>antioxidant activity ; chemiluminescence ; free radical inhibitory activity ; piperazinyl flavone analogs ; spectroscopy</subject><ispartof>Future medicinal chemistry, 2018-10, Vol.10 (19), p.2293-2308</ispartof><rights>2018 Newlands Press</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids></links><search><creatorcontrib>K adna, Aleksandra</creatorcontrib><creatorcontrib>Berczy ski, Pawe</creatorcontrib><creatorcontrib>Dündar, Oya Bozda</creatorcontrib><creatorcontrib>Ünlüsoy, Meltem Ceylan</creatorcontrib><creatorcontrib>Sar, Elmas</creatorcontrib><creatorcontrib>Bakinowska, Bernadetta</creatorcontrib><creatorcontrib>Kruk, Irena</creatorcontrib><creatorcontrib>Aboul-Enein, Hassan Y</creatorcontrib><title>Synthesis and</title><title>Future medicinal chemistry</title><description>Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity.
Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their
antioxidant potency by employing various antioxidant assays.
All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%), 2,2-diphenyl-1-picrylhydrazyl
(17-48%) at 1.25 and 0.5 mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1 μm trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7 μm trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.</description><subject>antioxidant activity</subject><subject>chemiluminescence</subject><subject>free radical inhibitory activity</subject><subject>piperazinyl flavone analogs</subject><subject>spectroscopy</subject><issn>1756-8919</issn><issn>1756-8927</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNpjYBA1NNAzMTQ11U_LTdY1MjC00DUwMjBjYuA0NDc107WwNDJngbMNLTkYeIuLswyAwNjIwtLMlJOBN7gyryQjtTizWCExL4WHgTUtMac4lRdKczNYurmGOHvoppWWlBalFidnpuYlp8ZDeLmpKZnJmXmp8YYG8SAnxAOdEA9yQjzICcaU6AUA_rU8gw</recordid><startdate>20181001</startdate><enddate>20181001</enddate><creator>K adna, Aleksandra</creator><creator>Berczy ski, Pawe</creator><creator>Dündar, Oya Bozda</creator><creator>Ünlüsoy, Meltem Ceylan</creator><creator>Sar, Elmas</creator><creator>Bakinowska, Bernadetta</creator><creator>Kruk, Irena</creator><creator>Aboul-Enein, Hassan Y</creator><general>Future Science Ltd</general><scope/></search><sort><creationdate>20181001</creationdate><title>Synthesis and</title><author>K adna, Aleksandra ; Berczy ski, Pawe ; Dündar, Oya Bozda ; Ünlüsoy, Meltem Ceylan ; Sar, Elmas ; Bakinowska, Bernadetta ; Kruk, Irena ; Aboul-Enein, Hassan Y</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-futurescience_futuremedicine_10_4155_fmc_2018_02063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>antioxidant activity</topic><topic>chemiluminescence</topic><topic>free radical inhibitory activity</topic><topic>piperazinyl flavone analogs</topic><topic>spectroscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>K adna, Aleksandra</creatorcontrib><creatorcontrib>Berczy ski, Pawe</creatorcontrib><creatorcontrib>Dündar, Oya Bozda</creatorcontrib><creatorcontrib>Ünlüsoy, Meltem Ceylan</creatorcontrib><creatorcontrib>Sar, Elmas</creatorcontrib><creatorcontrib>Bakinowska, Bernadetta</creatorcontrib><creatorcontrib>Kruk, Irena</creatorcontrib><creatorcontrib>Aboul-Enein, Hassan Y</creatorcontrib><jtitle>Future medicinal chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>K adna, Aleksandra</au><au>Berczy ski, Pawe</au><au>Dündar, Oya Bozda</au><au>Ünlüsoy, Meltem Ceylan</au><au>Sar, Elmas</au><au>Bakinowska, Bernadetta</au><au>Kruk, Irena</au><au>Aboul-Enein, Hassan Y</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and</atitle><jtitle>Future medicinal chemistry</jtitle><date>2018-10-01</date><risdate>2018</risdate><volume>10</volume><issue>19</issue><spage>2293</spage><epage>2308</epage><pages>2293-2308</pages><issn>1756-8919</issn><eissn>1756-8927</eissn><abstract>Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity.
Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their
antioxidant potency by employing various antioxidant assays.
All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%), 2,2-diphenyl-1-picrylhydrazyl
(17-48%) at 1.25 and 0.5 mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1 μm trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7 μm trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.</abstract><pub>Future Science Ltd</pub><doi>10.4155/fmc-2018-0206</doi></addata></record> |
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| ispartof | Future medicinal chemistry, 2018-10, Vol.10 (19), p.2293-2308 |
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| language | eng |
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| source | PubMed Central |
| subjects | antioxidant activity chemiluminescence free radical inhibitory activity piperazinyl flavone analogs spectroscopy |
| title | Synthesis and |
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