3-Benzyl(phenethyl)-2-thioxobenzo

Using a simple modification on a previously reported synthetic route, 3-benzyl(phenethyl)-2-thioxobenzo[ ]quinazolin-4(3 )-ones ( and ) were synthesized with high yields. Further transformation of and produced derivatives - , which were structurally characterized based on NMR and MS data, and their α-glucosidase inhibitory activity was evaluated using Baker's yeast α-glucosidase enzyme. Compounds , , , and exhibited the highest activity (IC = 69.20, 59.60, 49.40, 50.20 and 83.20 μM, respectively) compared with the standard acarbose (IC = 143.54 μM). A new class of potent α-glucosidase inhibitors was identified, and the molecular docking predicted plausible binding interaction of the targets in the binding pocket of α-glucosidase and rationalized the structure-activity relationship (SARs) of the target compounds.