Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of
Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier. Mannitol micropar...
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| Veröffentlicht in: | Nanomedicine (London, England) England), 2017-01, Vol.12 (1), p.25-42 |
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| container_title | Nanomedicine (London, England) |
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| creator | Craparo, Emanuela F Porsio, Barbara Schillaci, Domenico Cusimano, Maria G Spigolon, Dario Giammona, Gaetano Cavallaro, Gennara |
| description | Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier.
Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus.
MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in
infections if compared with free tobramycin.
MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems. |
| doi_str_mv | 10.2217/nnm-2016-0262 |
| format | Article |
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Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus.
MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in
infections if compared with free tobramycin.
MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems.</description><identifier>ISSN: 1743-5889</identifier><identifier>EISSN: 1748-6963</identifier><identifier>DOI: 10.2217/nnm-2016-0262</identifier><language>eng</language><publisher>Future Medicine Ltd</publisher><subject>cystic fibrosis artificial mucus ; infections ; mannitol ; microparticles ; nano into micro strategy ; spray dryer ; tobramycin ; α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide</subject><ispartof>Nanomedicine (London, England), 2017-01, Vol.12 (1), p.25-42</ispartof><rights>Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids></links><search><creatorcontrib>Craparo, Emanuela F</creatorcontrib><creatorcontrib>Porsio, Barbara</creatorcontrib><creatorcontrib>Schillaci, Domenico</creatorcontrib><creatorcontrib>Cusimano, Maria G</creatorcontrib><creatorcontrib>Spigolon, Dario</creatorcontrib><creatorcontrib>Giammona, Gaetano</creatorcontrib><creatorcontrib>Cavallaro, Gennara</creatorcontrib><title>Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of</title><title>Nanomedicine (London, England)</title><description>Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier.
Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus.
MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in
infections if compared with free tobramycin.
MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems.</description><subject>cystic fibrosis artificial mucus</subject><subject>infections</subject><subject>mannitol</subject><subject>microparticles</subject><subject>nano into micro strategy</subject><subject>spray dryer</subject><subject>tobramycin</subject><subject>α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide</subject><issn>1743-5889</issn><issn>1748-6963</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid/><recordid>eNqlj7FOAzEQRC0EEgFSpvcPGGwfudzVEYiSAqW1jFkLI3s3svek5O-5A_6AamY0s1o9ITZG31trdg-IRVlteqVtby_EyuweB9WPfXf54zu1HYbxWty09qX1drBGr8ThlfLZYyJUTO_Vl3NIKNEjBSrHDCdoMiGTjBMGnmc-y5JCpaOvnEKe60hV8idIruC5ALKkeCeuos8N1n96K8bnp7f9i4oTTxVaSIAB3G8q8JHmr-CMdguIm0HcAuIWkO4_t9_TmljS</recordid><startdate>20170101</startdate><enddate>20170101</enddate><creator>Craparo, Emanuela F</creator><creator>Porsio, Barbara</creator><creator>Schillaci, Domenico</creator><creator>Cusimano, Maria G</creator><creator>Spigolon, Dario</creator><creator>Giammona, Gaetano</creator><creator>Cavallaro, Gennara</creator><general>Future Medicine Ltd</general><scope/></search><sort><creationdate>20170101</creationdate><title>Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of</title><author>Craparo, Emanuela F ; Porsio, Barbara ; Schillaci, Domenico ; Cusimano, Maria G ; Spigolon, Dario ; Giammona, Gaetano ; Cavallaro, Gennara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-futurescience_futuremedicine_10_2217_nnm_2016_02623</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>cystic fibrosis artificial mucus</topic><topic>infections</topic><topic>mannitol</topic><topic>microparticles</topic><topic>nano into micro strategy</topic><topic>spray dryer</topic><topic>tobramycin</topic><topic>α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Craparo, Emanuela F</creatorcontrib><creatorcontrib>Porsio, Barbara</creatorcontrib><creatorcontrib>Schillaci, Domenico</creatorcontrib><creatorcontrib>Cusimano, Maria G</creatorcontrib><creatorcontrib>Spigolon, Dario</creatorcontrib><creatorcontrib>Giammona, Gaetano</creatorcontrib><creatorcontrib>Cavallaro, Gennara</creatorcontrib><jtitle>Nanomedicine (London, England)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Craparo, Emanuela F</au><au>Porsio, Barbara</au><au>Schillaci, Domenico</au><au>Cusimano, Maria G</au><au>Spigolon, Dario</au><au>Giammona, Gaetano</au><au>Cavallaro, Gennara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of</atitle><jtitle>Nanomedicine (London, England)</jtitle><date>2017-01-01</date><risdate>2017</risdate><volume>12</volume><issue>1</issue><spage>25</spage><epage>42</epage><pages>25-42</pages><issn>1743-5889</issn><eissn>1748-6963</eissn><abstract>Efficacy of antibiotics in cystic fibrosis (CF) is compromised by the poor penetration through mucus barrier. This work proposes a new 'nano-into-micro' approach, used to obtain a combinatorial effect: achieve a sustained delivery of tobramycin and overcome mucus barrier.
Mannitol microparticles (MPs) were loaded with a tobramycin polymeric nanocomplex and characterized in presence of CF artificial mucus.
MPs are able to alter the rheological properties of CF artificial mucus, enhancing drug penetration into it and allowing a prolonged drug release. MPs resulted to be effective in
infections if compared with free tobramycin.
MPs resulted to be a formulation of higher efficacy, with potential positive implications, as lower required dose, administration frequency, side effects and antibiotic resistance problems.</abstract><pub>Future Medicine Ltd</pub><doi>10.2217/nnm-2016-0262</doi></addata></record> |
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| ispartof | Nanomedicine (London, England), 2017-01, Vol.12 (1), p.25-42 |
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| language | eng |
| recordid | cdi_futurescience_futuremedicine_10_2217_nnm_2016_0262 |
| source | PubMed Central |
| subjects | cystic fibrosis artificial mucus infections mannitol microparticles nano into micro strategy spray dryer tobramycin α,β-poly(N-2-hydroxyethyl)-D,L-aspartamide |
| title | Polyanion-tobramycin nanocomplexes into functional microparticles for the treatment of |
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