Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea
Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA. We analyzed clusterin an...
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| Veröffentlicht in: | Biomarkers in medicine 2021-04, Vol.15 (5), p.323-330 |
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| creator | Meszaros, Martina Horvath, Peter Kis, Adrian Kunos, Laszlo Tarnoki, Adam D Tarnoki, David L Lazar, Zsofia Bikov, Andras |
| description | Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA.
We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.
There was no difference in CFH levels between patients (1099.4/784.6–1570.5/μg/ml) and controls (1051.4/652.0–1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2–763.2/μg/ml vs 276.1/131.0–424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).
Increase in clusterin levels may be protective in OSA by blocking the MAC formation. |
| doi_str_mv | 10.2217/bmm-2020-0533 |
| format | Article |
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We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.
There was no difference in CFH levels between patients (1099.4/784.6–1570.5/μg/ml) and controls (1051.4/652.0–1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2–763.2/μg/ml vs 276.1/131.0–424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).
Increase in clusterin levels may be protective in OSA by blocking the MAC formation.</description><identifier>ISSN: 1752-0363</identifier><identifier>EISSN: 1752-0371</identifier><identifier>DOI: 10.2217/bmm-2020-0533</identifier><identifier>PMID: 33666516</identifier><language>eng</language><publisher>England: Future Medicine Ltd</publisher><subject>Biomarkers - blood ; Case-Control Studies ; Clusterin - blood ; Complement Factor H - metabolism ; complement system ; Female ; Humans ; inflammation ; Male ; Middle Aged ; OSA ; sleep apnea ; Sleep Apnea, Obstructive - blood ; Sleep Apnea, Obstructive - diagnosis ; Sleep Apnea, Obstructive - epidemiology ; United Kingdom - epidemiology</subject><ispartof>Biomarkers in medicine, 2021-04, Vol.15 (5), p.323-330</ispartof><rights>2021 Future Medicine Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c382t-f3c3002870ae33033459e59fb283c3c651769f36ba62c2e93fcdd57ec15e7e303</citedby><cites>FETCH-LOGICAL-c382t-f3c3002870ae33033459e59fb283c3c651769f36ba62c2e93fcdd57ec15e7e303</cites><orcidid>0000-0001-5909-3780 ; 0000-0003-2444-9040 ; 0000-0003-1065-3577 ; 0000-0002-7001-7647 ; 0000-0001-9966-5747 ; 0000-0002-1583-8143 ; 0000-0002-8983-740X ; 0000-0002-3371-7097</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33666516$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Meszaros, Martina</creatorcontrib><creatorcontrib>Horvath, Peter</creatorcontrib><creatorcontrib>Kis, Adrian</creatorcontrib><creatorcontrib>Kunos, Laszlo</creatorcontrib><creatorcontrib>Tarnoki, Adam D</creatorcontrib><creatorcontrib>Tarnoki, David L</creatorcontrib><creatorcontrib>Lazar, Zsofia</creatorcontrib><creatorcontrib>Bikov, Andras</creatorcontrib><title>Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea</title><title>Biomarkers in medicine</title><addtitle>Biomark Med</addtitle><description>Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA.
We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.
There was no difference in CFH levels between patients (1099.4/784.6–1570.5/μg/ml) and controls (1051.4/652.0–1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2–763.2/μg/ml vs 276.1/131.0–424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).
Increase in clusterin levels may be protective in OSA by blocking the MAC formation.</description><subject>Biomarkers - blood</subject><subject>Case-Control Studies</subject><subject>Clusterin - blood</subject><subject>Complement Factor H - metabolism</subject><subject>complement system</subject><subject>Female</subject><subject>Humans</subject><subject>inflammation</subject><subject>Male</subject><subject>Middle Aged</subject><subject>OSA</subject><subject>sleep apnea</subject><subject>Sleep Apnea, Obstructive - blood</subject><subject>Sleep Apnea, Obstructive - diagnosis</subject><subject>Sleep Apnea, Obstructive - epidemiology</subject><subject>United Kingdom - epidemiology</subject><issn>1752-0363</issn><issn>1752-0371</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kDtPwzAURi0EoqUwsiKPLAHHbuxkRBVQpEosMBvHuQYj54HtFPHvcZXSjcmPe75PVwehy5zcUJqL27ptM0ooyUjB2BGa56KgGWEiPz7cOZuhsxA-CSmE4PQUzRjjnBc5n6O3lfV6dCra7h072IILuDdYuzFE8LbDqmuw7tvBQQtdxEbp2Hu8xmk0pFT6C_jbxg_c1yH6UUe7BRwcwIDV0IE6RydGuQAX-3OBXh_uX1brbPP8-LS622SalTRmhmlGCC0FUcAYYWxZVFBUpqZlmui0rOCVYbxWnGoKFTO6aQoBOi9AQAos0PXUO_j-a4QQZWuDBudUB_0YJF1W5bKktKwSmk2o9n0IHowcvG2V_5E5kTupMkmVO6lyJzXxV_vqsW6hOdB_FhNQTYAZ4-gh6KRFg5xeKWG17eCf8l-27obD</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Meszaros, Martina</creator><creator>Horvath, Peter</creator><creator>Kis, Adrian</creator><creator>Kunos, Laszlo</creator><creator>Tarnoki, Adam D</creator><creator>Tarnoki, David L</creator><creator>Lazar, Zsofia</creator><creator>Bikov, Andras</creator><general>Future Medicine Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5909-3780</orcidid><orcidid>https://orcid.org/0000-0003-2444-9040</orcidid><orcidid>https://orcid.org/0000-0003-1065-3577</orcidid><orcidid>https://orcid.org/0000-0002-7001-7647</orcidid><orcidid>https://orcid.org/0000-0001-9966-5747</orcidid><orcidid>https://orcid.org/0000-0002-1583-8143</orcidid><orcidid>https://orcid.org/0000-0002-8983-740X</orcidid><orcidid>https://orcid.org/0000-0002-3371-7097</orcidid></search><sort><creationdate>20210401</creationdate><title>Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea</title><author>Meszaros, Martina ; Horvath, Peter ; Kis, Adrian ; Kunos, Laszlo ; Tarnoki, Adam D ; Tarnoki, David L ; Lazar, Zsofia ; Bikov, Andras</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c382t-f3c3002870ae33033459e59fb283c3c651769f36ba62c2e93fcdd57ec15e7e303</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Biomarkers - blood</topic><topic>Case-Control Studies</topic><topic>Clusterin - blood</topic><topic>Complement Factor H - metabolism</topic><topic>complement system</topic><topic>Female</topic><topic>Humans</topic><topic>inflammation</topic><topic>Male</topic><topic>Middle Aged</topic><topic>OSA</topic><topic>sleep apnea</topic><topic>Sleep Apnea, Obstructive - blood</topic><topic>Sleep Apnea, Obstructive - diagnosis</topic><topic>Sleep Apnea, Obstructive - epidemiology</topic><topic>United Kingdom - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Meszaros, Martina</creatorcontrib><creatorcontrib>Horvath, Peter</creatorcontrib><creatorcontrib>Kis, Adrian</creatorcontrib><creatorcontrib>Kunos, Laszlo</creatorcontrib><creatorcontrib>Tarnoki, Adam D</creatorcontrib><creatorcontrib>Tarnoki, David L</creatorcontrib><creatorcontrib>Lazar, Zsofia</creatorcontrib><creatorcontrib>Bikov, Andras</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biomarkers in medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Meszaros, Martina</au><au>Horvath, Peter</au><au>Kis, Adrian</au><au>Kunos, Laszlo</au><au>Tarnoki, Adam D</au><au>Tarnoki, David L</au><au>Lazar, Zsofia</au><au>Bikov, Andras</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea</atitle><jtitle>Biomarkers in medicine</jtitle><addtitle>Biomark Med</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>15</volume><issue>5</issue><spage>323</spage><epage>330</epage><pages>323-330</pages><issn>1752-0363</issn><eissn>1752-0371</eissn><abstract>Obstructive sleep apnea (OSA) activates the complement system; however, the levels of membrane attack complex (MAC) are unaltered suggesting regulatory mechanisms. Our aim was to investigate complement factor H (CFH) and clusterin, two important complement regulators in OSA.
We analyzed clusterin and CFH levels in plasma of 86 patients with OSA and 33 control subjects.
There was no difference in CFH levels between patients (1099.4/784.6–1570.5/μg/ml) and controls (1051.4/652.0–1615.1/μg/ml, p = 0.72). Clusterin levels were higher in patients with OSA (309.7/217.2–763.2/μg/ml vs 276.1/131.0–424.3/μg/ml, p = 0.048) with a trend for a positive correlation with disease severity (p = 0.073).
Increase in clusterin levels may be protective in OSA by blocking the MAC formation.</abstract><cop>England</cop><pub>Future Medicine Ltd</pub><pmid>33666516</pmid><doi>10.2217/bmm-2020-0533</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5909-3780</orcidid><orcidid>https://orcid.org/0000-0003-2444-9040</orcidid><orcidid>https://orcid.org/0000-0003-1065-3577</orcidid><orcidid>https://orcid.org/0000-0002-7001-7647</orcidid><orcidid>https://orcid.org/0000-0001-9966-5747</orcidid><orcidid>https://orcid.org/0000-0002-1583-8143</orcidid><orcidid>https://orcid.org/0000-0002-8983-740X</orcidid><orcidid>https://orcid.org/0000-0002-3371-7097</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; PubMed Central |
| subjects | Biomarkers - blood Case-Control Studies Clusterin - blood Complement Factor H - metabolism complement system Female Humans inflammation Male Middle Aged OSA sleep apnea Sleep Apnea, Obstructive - blood Sleep Apnea, Obstructive - diagnosis Sleep Apnea, Obstructive - epidemiology United Kingdom - epidemiology |
| title | Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea |
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