Expansion of gene clusters, circular orders, and the shortest Hamiltonian path problem

Clusters of paralogous genes such as the famous HOX cluster of developmental transcription factors tend to evolve by stepwise duplication of its members, often involving unequal crossing over. Gene conversion and possibly other mechanisms of concerted evolution further obfuscate the phylogenetic rel...

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Bibliographische Detailangaben

Hauptverfasser:	Prohaska, Sonja J, Berkemer, Sarah J, Gärtner, Fabian, Gatter, Thomas, Retzlaff, Nancy, Höner zu Siederdissen, Christian, Stadler, Peter F
Format:	Artikel
Sprache:	eng
Schlagworte:	evolution of gene cluster Hamiltonian path problem Kalmanson metric non-homologous recombination phylogenetic combinatoric unequal crossing over
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