Activated platelets release sphingosine 1-phosphate and induce hypersensitivity to noxious heat stimuli in vivo
At the site of injury activated platelets release various mediators, one of which is sphingosine 1-phosphate (S1P). It was the aim of this study to explore whether activated human platelets had a pronociceptive effect in an in vivo mouse model and whether this effect was based on the release of S1P...
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