Direct antidiabetic effect of leptin through triglyceride depletion of tissues
Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1997-04, Vol.94 (9), p.4637-4641 |
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| creator | Shimabukuro, M. (University of Texas Southwestern Medical Center, Dallas, TX.) Koyama, K Chen, G Wang, M.Y Trieu, F Lee, Y Newgard, C.B Unger, R.H |
| description | Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. In cultured pancreatic islets, leptin lowered triglyceride (TG) content by preventing TG formation from free fatty acids (FFA) and by increasing FFA oxidation. In vivo hyperleptinemia, induced in normal rats by adenovirus gene transfer, depleted TG content in liver, skeletal muscle, and pancreas without increasing plasma FFA or ketones, suggesting intracellular oxidation. In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. The TG content was approximately 20 times normal, and esterification capacity was increased 3- to 4-fold. Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes sterify FFA, store them as TG, and later oxidize them intracellularly via an "indirect pathway" of intracellular fatty acid metabolism controlled by leptin. By maintaining insulin sensitivity and preventing islet lipotoxicity, this activity of leptin may prevent adipogenic diabetes |
| doi_str_mv | 10.1073/pnas.94.9.4637 |
| format | Article |
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(University of Texas Southwestern Medical Center, Dallas, TX.) ; Koyama, K ; Chen, G ; Wang, M.Y ; Trieu, F ; Lee, Y ; Newgard, C.B ; Unger, R.H</creator><creatorcontrib>Shimabukuro, M. (University of Texas Southwestern Medical Center, Dallas, TX.) ; Koyama, K ; Chen, G ; Wang, M.Y ; Trieu, F ; Lee, Y ; Newgard, C.B ; Unger, R.H</creatorcontrib><description>Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. In cultured pancreatic islets, leptin lowered triglyceride (TG) content by preventing TG formation from free fatty acids (FFA) and by increasing FFA oxidation. In vivo hyperleptinemia, induced in normal rats by adenovirus gene transfer, depleted TG content in liver, skeletal muscle, and pancreas without increasing plasma FFA or ketones, suggesting intracellular oxidation. In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. The TG content was approximately 20 times normal, and esterification capacity was increased 3- to 4-fold. Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes sterify FFA, store them as TG, and later oxidize them intracellularly via an "indirect pathway" of intracellular fatty acid metabolism controlled by leptin. By maintaining insulin sensitivity and preventing islet lipotoxicity, this activity of leptin may prevent adipogenic diabetes</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.94.9.4637</identifier><identifier>PMID: 9114043</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>3-Hydroxybutyric Acid ; ACIDE GRAS ; ACIDE PALMITIQUE ; ACIDO PALMITICO ; ACIDOS GRASOS ; Anatomy & physiology ; Animals ; Biological Sciences ; Body fat ; Carrier Proteins - metabolism ; Culture Techniques ; Diabetes ; Diabetes Mellitus, Experimental - genetics ; Diabetes Mellitus, Experimental - metabolism ; ESTERIFICACION ; ESTERIFICATION ; Esterification - drug effects ; Fatty Acids, Nonesterified - blood ; FOIE ; Food intake ; Genotype ; HEMOLIPIDOS ; HIGADO ; HORMONAS ; HORMONE ; Hormones ; HUESOS ; Hydroxybutyrates - blood ; Hypoglycemic Agents - pharmacology ; INGESTION DE ALIMENTOS ; Islets of Langerhans - drug effects ; Leptin ; LIPIDE SANGUIN ; Liver ; Liver - metabolism ; Male ; METABOLISME DES LIPIDES ; METABOLISMO DE LIPIDOS ; Muscle, Skeletal - metabolism ; Nonesterified fatty acids ; Obesity ; OXIDACION ; Oxidation ; Oxidation-Reduction - drug effects ; OXYDATION ; PANCREAS ; PEPTIDE ; Peptides ; PEPTIDOS ; PESO ; POIDS ; PRISE ALIMENTAIRE (HOMME) ; Proteins - genetics ; Proteins - pharmacology ; RAT ; RATA ; Rats ; Rats, Wistar ; Rats, Zucker ; Receptors ; Receptors, Cell Surface ; Receptors, Leptin ; Recombinant Fusion Proteins - pharmacology ; Species Specificity ; TRANSFERENCIA DE GENES ; TRANSFERT DE GENE ; TRASTORNOS METABOLICOS ; TRIGLICERIDOS ; TRIGLYCERIDE ; Triglycerides ; Triglycerides - metabolism ; TROUBLE DU METABOLISME ; Weight</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (9), p.4637-4641</ispartof><rights>Copyright 1997 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Apr 29, 1997</rights><rights>Copyright © 1997, The National Academy of Sciences of the USA 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c567t-9e558917d880c74ab48bda73994fd84731c5d57c3a1cff85a9508d92c58786473</citedby><cites>FETCH-LOGICAL-c567t-9e558917d880c74ab48bda73994fd84731c5d57c3a1cff85a9508d92c58786473</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/94/9.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/42064$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/42064$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9114043$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Shimabukuro, M. (University of Texas Southwestern Medical Center, Dallas, TX.)</creatorcontrib><creatorcontrib>Koyama, K</creatorcontrib><creatorcontrib>Chen, G</creatorcontrib><creatorcontrib>Wang, M.Y</creatorcontrib><creatorcontrib>Trieu, F</creatorcontrib><creatorcontrib>Lee, Y</creatorcontrib><creatorcontrib>Newgard, C.B</creatorcontrib><creatorcontrib>Unger, R.H</creatorcontrib><title>Direct antidiabetic effect of leptin through triglyceride depletion of tissues</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. In cultured pancreatic islets, leptin lowered triglyceride (TG) content by preventing TG formation from free fatty acids (FFA) and by increasing FFA oxidation. In vivo hyperleptinemia, induced in normal rats by adenovirus gene transfer, depleted TG content in liver, skeletal muscle, and pancreas without increasing plasma FFA or ketones, suggesting intracellular oxidation. In islets of obese Zucker Diabetic Fatty rats with leptin receptor mutations, leptin had no effect in vivo or in vitro. The TG content was approximately 20 times normal, and esterification capacity was increased 3- to 4-fold. Thus, in rats with normal leptin receptors but not in Zucker Diabetic Fatty rats, nonadipocytes and adipocytes sterify FFA, store them as TG, and later oxidize them intracellularly via an "indirect pathway" of intracellular fatty acid metabolism controlled by leptin. 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(University of Texas Southwestern Medical Center, Dallas, TX.)</creatorcontrib><creatorcontrib>Koyama, K</creatorcontrib><creatorcontrib>Chen, G</creatorcontrib><creatorcontrib>Wang, M.Y</creatorcontrib><creatorcontrib>Trieu, F</creatorcontrib><creatorcontrib>Lee, Y</creatorcontrib><creatorcontrib>Newgard, C.B</creatorcontrib><creatorcontrib>Unger, R.H</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Shimabukuro, M. (University of Texas Southwestern Medical Center, Dallas, TX.)</au><au>Koyama, K</au><au>Chen, G</au><au>Wang, M.Y</au><au>Trieu, F</au><au>Lee, Y</au><au>Newgard, C.B</au><au>Unger, R.H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Direct antidiabetic effect of leptin through triglyceride depletion of tissues</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1997-04-29</date><risdate>1997</risdate><volume>94</volume><issue>9</issue><spage>4637</spage><epage>4641</epage><pages>4637-4641</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Leptin is currently believed to control body composition largely, if not entirely, via hypothalamic receptors that regulate food intake and thermogenesis. Here we demonstrate direct extraneural effects of leptin to deplete fat content of both adipocytes and nonadipocytes to levels far below those of pairfed controls. 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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1997-04, Vol.94 (9), p.4637-4641 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_fao_agris_US9743808 |
| source | MEDLINE; JSTOR Archive Collection A-Z Listing; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | 3-Hydroxybutyric Acid ACIDE GRAS ACIDE PALMITIQUE ACIDO PALMITICO ACIDOS GRASOS Anatomy & physiology Animals Biological Sciences Body fat Carrier Proteins - metabolism Culture Techniques Diabetes Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism ESTERIFICACION ESTERIFICATION Esterification - drug effects Fatty Acids, Nonesterified - blood FOIE Food intake Genotype HEMOLIPIDOS HIGADO HORMONAS HORMONE Hormones HUESOS Hydroxybutyrates - blood Hypoglycemic Agents - pharmacology INGESTION DE ALIMENTOS Islets of Langerhans - drug effects Leptin LIPIDE SANGUIN Liver Liver - metabolism Male METABOLISME DES LIPIDES METABOLISMO DE LIPIDOS Muscle, Skeletal - metabolism Nonesterified fatty acids Obesity OXIDACION Oxidation Oxidation-Reduction - drug effects OXYDATION PANCREAS PEPTIDE Peptides PEPTIDOS PESO POIDS PRISE ALIMENTAIRE (HOMME) Proteins - genetics Proteins - pharmacology RAT RATA Rats Rats, Wistar Rats, Zucker Receptors Receptors, Cell Surface Receptors, Leptin Recombinant Fusion Proteins - pharmacology Species Specificity TRANSFERENCIA DE GENES TRANSFERT DE GENE TRASTORNOS METABOLICOS TRIGLICERIDOS TRIGLYCERIDE Triglycerides Triglycerides - metabolism TROUBLE DU METABOLISME Weight |
| title | Direct antidiabetic effect of leptin through triglyceride depletion of tissues |
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