Developmental regulation of an insulin-degrading enzyme from Drosophila melanogaster

The precise mechanism by which insulin is degraded in mammalian cells is not presently known. Several lines of evidence suggest that degradation is initiated by a specific nonlysosomal insulin-degrading enzyme (IDE). The potential importance of this insulin protease is illustrated by the fact that t...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1988-05, Vol.85 (10), p.3469-3473
Hauptverfasser:	Stoppelli, M.P, Garcia, J.V, Decker, S.J, Rosner, M.R
Format:	Artikel
Sprache:	eng
Schlagworte:	ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Animals Antibodies Antiserum Biological and medical sciences Cell Differentiation - drug effects Cell extracts Cell Line Cell lines DEGRADATION DETERIORO DROSOPHILA Drosophila melanogaster Drosophila melanogaster - enzymology Drosophilidae Ecdysone - pharmacology Embryos Enzymes ENZYMIC ACTIVITY Fundamental and applied biological sciences. Psychology Gene expression Insect larvae INSULIN INSULINA INSULINE Insulysin - metabolism Kinetics Molecular and cellular biology Molecular genetics Peptide Hydrolases - metabolism Receptors
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