Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster
Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regul...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 1987-11, Vol.84 (22), p.8026-8030 |
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| creator | Belote, J.M Baker, B.S |
| description | Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult. |
| doi_str_mv | 10.1073/pnas.84.22.8026 |
| format | Article |
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Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.84.22.8026</identifier><identifier>PMID: 3120181</identifier><identifier>CODEN: PNASA6</identifier><language>eng</language><publisher>Washington, DC: National Academy of Sciences of the United States of America</publisher><subject>Adult insects ; Adulthood ; ANIMAL DEVELOPMENTAL STAGES ; Animals ; Biological and medical sciences ; Central nervous system ; Central Nervous System - physiology ; Classical genetics, quantitative genetics, hybrids ; COMPORTAMIENTO SEXUAL ; COMPORTEMENT SEXUEL ; CONTROL GENETICO ; Courtship ; DROSOPHILA ; Drosophila melanogaster ; Drosophila melanogaster - genetics ; Drosophila melanogaster - growth & development ; Drosophila melanogaster - physiology ; Drosophilidae ; Eclosion ; Egg Proteins - genetics ; ETAPAS DEL DESARROLLO ANIMAL ; Female ; Female animals ; Fundamental and applied biological sciences. Psychology ; Gene Expression Regulation ; GENETIC CONTROL ; Genetics of eukaryotes. Biological and molecular evolution ; Insect larvae ; Invertebrata ; LUTTE GENETIQUE ; MADUREZ SEXUAL ; Male ; Male animals ; Mating behavior ; MATURITE SEXUELLE ; Mutation ; Neuronal Plasticity ; Sex Differentiation ; Sexual Behavior, Animal ; SEXUAL BEHAVIOUR ; SEXUAL MATURITY ; STADE DE DEVELOPPEMENT ANIMAL ; Temperature</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (22), p.8026-8030</ispartof><rights>1988 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c542t-4946fd7f2a07a192fd6009110e4821d48ce7f8c93035a4b257447816f8c0936b3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/84/22.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/30594$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/30594$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,803,885,27924,27925,53791,53793,58017,58250</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=7793691$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/3120181$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Belote, J.M</creatorcontrib><creatorcontrib>Baker, B.S</creatorcontrib><title>Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.</description><subject>Adult insects</subject><subject>Adulthood</subject><subject>ANIMAL DEVELOPMENTAL STAGES</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Central nervous system</subject><subject>Central Nervous System - physiology</subject><subject>Classical genetics, quantitative genetics, hybrids</subject><subject>COMPORTAMIENTO SEXUAL</subject><subject>COMPORTEMENT SEXUEL</subject><subject>CONTROL GENETICO</subject><subject>Courtship</subject><subject>DROSOPHILA</subject><subject>Drosophila melanogaster</subject><subject>Drosophila melanogaster - genetics</subject><subject>Drosophila melanogaster - growth & development</subject><subject>Drosophila melanogaster - physiology</subject><subject>Drosophilidae</subject><subject>Eclosion</subject><subject>Egg Proteins - genetics</subject><subject>ETAPAS DEL DESARROLLO ANIMAL</subject><subject>Female</subject><subject>Female animals</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gene Expression Regulation</subject><subject>GENETIC CONTROL</subject><subject>Genetics of eukaryotes. Biological and molecular evolution</subject><subject>Insect larvae</subject><subject>Invertebrata</subject><subject>LUTTE GENETIQUE</subject><subject>MADUREZ SEXUAL</subject><subject>Male</subject><subject>Male animals</subject><subject>Mating behavior</subject><subject>MATURITE SEXUELLE</subject><subject>Mutation</subject><subject>Neuronal Plasticity</subject><subject>Sex Differentiation</subject><subject>Sexual Behavior, Animal</subject><subject>SEXUAL BEHAVIOUR</subject><subject>SEXUAL MATURITY</subject><subject>STADE DE DEVELOPPEMENT ANIMAL</subject><subject>Temperature</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1987</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2PFCEQxYnRrOPq2cSo4WD01LNA0w2YeDDrZ7KJh3XPyNB0DxsGeoGerP-9dKYd3YueSHi_qnpVD4CnGK0xYvXZ6FVac7omZM0Rae-BFUYCVy0V6D5YIURYxSmhD8GjlK4RQqLh6ASc1JggzPEK_Lg0t5NycGO2am9DfAttTnAw3mSroQ4-x-BgN0XrB9iZvXFh3BmfofIdVN3k8jaEDloPP8SQwri1TsGdccqHQaVs4mPwoFcumSfLewquPn38fv6luvj2-ev5-4tKN5Tkigra9h3riUJMYUH6ri1mMUaGcoI7yrVhPdeiRnWj6IY0jFLGcVv-kKjbTX0K3h36jtNmZzpdPEbl5BjtTsWfMigr7yrebuUQ9pKIMlqU-tdLfQw3k0lZ7mzSxpVNTJiSZKz44Lz-L4ipwA0XqIBnB1CXy6Ro-qMZjOQcnpzDk5xKQuQcXql48fcOR35Jq-ivFl0lrVwfldc2HTHGyiXEjL1csLn_b_XOnDf_BGQ_OZfNbS7kswN5nXKIfwyhRtAiPj-IvQpSDbFYubrkHOOmpuVSvwAq6c1P</recordid><startdate>19871101</startdate><enddate>19871101</enddate><creator>Belote, J.M</creator><creator>Baker, B.S</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7SS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19871101</creationdate><title>Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster</title><author>Belote, J.M ; Baker, B.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c542t-4946fd7f2a07a192fd6009110e4821d48ce7f8c93035a4b257447816f8c0936b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1987</creationdate><topic>Adult insects</topic><topic>Adulthood</topic><topic>ANIMAL DEVELOPMENTAL STAGES</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Central nervous system</topic><topic>Central Nervous System - physiology</topic><topic>Classical genetics, quantitative genetics, hybrids</topic><topic>COMPORTAMIENTO SEXUAL</topic><topic>COMPORTEMENT SEXUEL</topic><topic>CONTROL GENETICO</topic><topic>Courtship</topic><topic>DROSOPHILA</topic><topic>Drosophila melanogaster</topic><topic>Drosophila melanogaster - genetics</topic><topic>Drosophila melanogaster - growth & development</topic><topic>Drosophila melanogaster - physiology</topic><topic>Drosophilidae</topic><topic>Eclosion</topic><topic>Egg Proteins - genetics</topic><topic>ETAPAS DEL DESARROLLO ANIMAL</topic><topic>Female</topic><topic>Female animals</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gene Expression Regulation</topic><topic>GENETIC CONTROL</topic><topic>Genetics of eukaryotes. Biological and molecular evolution</topic><topic>Insect larvae</topic><topic>Invertebrata</topic><topic>LUTTE GENETIQUE</topic><topic>MADUREZ SEXUAL</topic><topic>Male</topic><topic>Male animals</topic><topic>Mating behavior</topic><topic>MATURITE SEXUELLE</topic><topic>Mutation</topic><topic>Neuronal Plasticity</topic><topic>Sex Differentiation</topic><topic>Sexual Behavior, Animal</topic><topic>SEXUAL BEHAVIOUR</topic><topic>SEXUAL MATURITY</topic><topic>STADE DE DEVELOPPEMENT ANIMAL</topic><topic>Temperature</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Belote, J.M</creatorcontrib><creatorcontrib>Baker, B.S</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Belote, J.M</au><au>Baker, B.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1987-11-01</date><risdate>1987</risdate><volume>84</volume><issue>22</issue><spage>8026</spage><epage>8030</epage><pages>8026-8030</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><coden>PNASA6</coden><abstract>Courtship behavior in Drosophila melanogaster males is an innate behavior pattern. Whether or not a fly will display male courtship behavior is governed by the action of a set of regulatory genes that control all aspects of somatic sexual differentiation. The wild-type function of one of these regulatory genes, transformer-2 (tra-2), is necessary for female sexual differentiation; in the absence of tra-2+ function XX individuals differentiate as males. A temperature-sensitive tra-2 allele has been used to investigate, by means of temperature shifts, when and how male courtship behavior is specified during development. The removal of tra-2ts function in the adult (by a shift of the tra-2ts mutant flies to the restrictive temperature) can lead to the appearance of male courtship behavior in flies that otherwise would not display these behaviors. These experiments suggest that the regulatory hierarchy controlling sexual differentiation is functioning in the adult central nervous system. More importantly, these results suggest that the adult central nervous system has some functional plasticity with respect to the innate behavioral pattern of male courtship and is maintained in a particular state of differentiation by the active control of gene expression in the adult.</abstract><cop>Washington, DC</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>3120181</pmid><doi>10.1073/pnas.84.22.8026</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1987-11, Vol.84 (22), p.8026-8030 |
| issn | 0027-8424 1091-6490 |
| language | eng |
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| source | Open Access: PubMed Central; MEDLINE; Full-Text Journals in Chemistry (Open access); Alma/SFX Local Collection; JSTOR |
| subjects | Adult insects Adulthood ANIMAL DEVELOPMENTAL STAGES Animals Biological and medical sciences Central nervous system Central Nervous System - physiology Classical genetics, quantitative genetics, hybrids COMPORTAMIENTO SEXUAL COMPORTEMENT SEXUEL CONTROL GENETICO Courtship DROSOPHILA Drosophila melanogaster Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Drosophila melanogaster - physiology Drosophilidae Eclosion Egg Proteins - genetics ETAPAS DEL DESARROLLO ANIMAL Female Female animals Fundamental and applied biological sciences. Psychology Gene Expression Regulation GENETIC CONTROL Genetics of eukaryotes. Biological and molecular evolution Insect larvae Invertebrata LUTTE GENETIQUE MADUREZ SEXUAL Male Male animals Mating behavior MATURITE SEXUELLE Mutation Neuronal Plasticity Sex Differentiation Sexual Behavior, Animal SEXUAL BEHAVIOUR SEXUAL MATURITY STADE DE DEVELOPPEMENT ANIMAL Temperature |
| title | Sexual behavior: its genetic control during development and adulthood in Drosophila melanogaster |
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