Loss of insulin response to glucose but not arginine during the development of autoimmune diabetes in BB/W rats: relationships to islet volume and glucose transport rate

The insulin and glucagon responses to 10 mM glucose and 10 mM arginine were studied in pancreata isolated from nondiabetic diabetes-prone and diabetes-resistant BB/W rats at 60, 80, and 140 days of age and in diabetic BB/W rats on the 1st and 14th days of their diabetes. In the former group the insu...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1986-12, Vol.83 (24), p.9749-9753
Hauptverfasser:	Tominaga, M, Komiya, I, Johnson, J.H, Inman, L, Alam, T, Moltz, J, Crider, B, Stefan, Y, Baetens, D, McCorkle, K, Orci, L, Unger, R.H
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Factors Animals arginine Arginine - pharmacology Autoimmune Diseases - physiopathology Autoimmunity (experimental aspects and models) Biological and medical sciences Biological Transport BLOOD DIABETE DIABETES Diabetes complications diabetes mellitus Diabetes Mellitus, Experimental - immunology Diabetes Mellitus, Experimental - pathology Diabetes Mellitus, Experimental - physiopathology DNA Fundamental and applied biological sciences. Psychology Fundamental immunology Glucagon - metabolism GLUCOSA GLUCOSE Glucose - metabolism Glucose - pharmacology Insulin Insulin - metabolism Insulin Secretion Islets of Langerhans - metabolism Islets of Langerhans - pathology NUTRIENT TRANSPORT PANCREAS Perfusion RAT RATA RATS Rats, Inbred Strains SANG SANGRE Secretory Rate - drug effects TRANSPORT DES SUBSTANCES NUTRITIVES TRANSPORTE DE NUTRIENTES Type 1 diabetes mellitus Type 2 diabetes mellitus
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