Structural basis for pregnenolone biosynthesis by the mitochondrial monooxygenase system

In humans, the precursor to all steroid hormones, pregnenolone, is synthesized from cholesterol by an enzyme complex comprising adrenodoxin reductase (AdR), adrenodoxin (Adx), and a cytochrome P450 (P450scc or CYP11A1). This complex not only plays a key role in steroidogenesis, but also has long bee...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-06, Vol.108 (25), p.10139-10143
Hauptverfasser:	Strushkevich, Natallia, MacKenzie, Farrell, Cherkesova, Tatyana, Grabovec, Irina, Usanov, Sergey, Park, Hee-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Active sites Adrenodoxin - chemistry Adrenodoxin - metabolism Animals BASIC BIOLOGICAL SCIENCES Biochemistry Biological Sciences BIOSYNTHESIS CATALYSIS catalytic activity Catalytic Domain Cattle chemical bonding CHOLESTEROL Cholesterol - metabolism Cholesterol Side-Chain Cleavage Enzyme - chemistry Cholesterol Side-Chain Cleavage Enzyme - metabolism Cholesterols CLEAVAGE Conservation CRYSTAL STRUCTURE Cytochrome cytochrome P-450 CYTOCHROMES ELECTRON TRANSFER Electrons electrostatic interactions ELECTROSTATICS ENZYMES Eukaryotes ferredoxin-NADP reductase GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE GEOMETRY HEME heme iron Humans HYDROXYPREGNENONE IRON MEMBRANES Mitochondria Mitochondria - enzymology Mixed Function Oxygenases - metabolism Models, Molecular Molecular interactions Molecules Oxidation-Reduction OXIDOREDUCTASES Oxygen PRECURSOR pregnenolone Pregnenolone - biosynthesis Protein Binding Protein Conformation Proteins REACTION INTERMEDIATES Static Electricity STEROID HORMONES steroidogenesis SUBSTRATES
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