Notch signaling drives IL-22 secretion in CD4⁺ T cells by stimulating the aryl hydrocarbon receptor

CD4⁺ helper T (Th) cells differentiate toward distinct effector cell lineages characterized by their distinct cytokine expression patterns and functions. Multiple Th cell populations secrete IL-22 that contributes to both protective and pathological inflammatory responses. Although the differentia...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010, Vol.107 (13), p.5943-5948
Hauptverfasser:	Alam, Muhammad Shamsul, Maekawa, Yoichi, Kitamura, Akiko, Tanigaki, Kenji, Yoshimoto, Takayuki, Kishihara, Kenji, Yasutomo, Koji
Format:	Artikel
Sprache:	eng
Schlagworte:	CD4-positive T-lymphocytes cytokines hepatitis immunopathology inflammation mice secretion
Online-Zugang:	Volltext
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