Morphine peripheral analgesia depends on activation of the PI3Kγ/AKT/nNOS/NO/KATP signaling pathway

Morphine is one of the most prescribed and effective drugs used for the treatment of acute and chronic pain conditions. In addition to its central effects, morphine can also produce peripheral analgesia. However, the mechanisms underlying this peripheral action of morphine have not yet been fully el...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010, Vol.107 (9), p.4442-4447
Hauptverfasser:	Cunha, Thiago M, Roman-Campos, Danilo, Lotufo, Celina M, Duarte, Hugo L, Souza, Guilherme R, Verri, Waldiceu A. Jr, Funez, Mani I, Dias, Quintino M, Schivo, Ieda R, Domingues, Andressa C, Sachs, Daniela, Chiavegatto, Silvana, Teixeira, Mauro M, Hothersall, John S, Cruz, Jader S, Cunha, Fernando Q, Ferreira, Sergio H
Format:	Artikel
Sprache:	eng
Schlagworte:	analgesia analgesic effect mice morphine neuronal nitric oxide synthase neurons nitric oxide non-specific serine/threonine protein kinase pain signal transduction
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!