Bovine cytochrome c oxidase structures enable O₂ reduction with minimization of reactive oxygens and provide a proton-pumping gate

The O₂ reduction site of cytochrome c oxidase (CcO), comprising iron (Fea₃) and copper (CuB) ions, is probed by x-ray structural analyses of CO, NO, and CN⁻ derivatives to investigate the mechanism of the complete reduction of O₂. Formation of the Formula derivative contributes to the trigon...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010, Vol.107 (17), p.7740-7745
Hauptverfasser:	Muramoto, Kazumasa, Ohta, Kazuhiro, Shinzawa-Itoh, Kyoko, Kanda, Katsumasa, Taniguchi, Maki, Nabekura, Hiroyuki, Yamashita, Eiki, Tsukihara, Tomitake, Yoshikawa, Shinya
Format:	Artikel
Sprache:	eng
Schlagworte:	active oxygen species carbon monoxide cattle copper cytochrome-c oxidase hydrogen bonding ions iron nitric oxide oxygen protons X-radiation
Online-Zugang:	Volltext
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