RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction

Intracellular amyloid-β peptide (Aβ) has been implicated in neuronal death associated with Alzheimer's disease. Although Aβ is predominantly secreted into the extracellular space, mechanisms of Aβ transport at the level of the neuronal cell membrane remain to be fully elucidated. We demonst...

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