α-Helix targeting reduces amyloid-β peptide toxicity

The amyloid-β peptide (Aβ) can generate cytotoxic oligomers, and their accumulation is thought to underlie the neuropathologic changes found in Alzheimer's disease. Known inhibitors of Aβ polymerization bind to undefined structures and can work as nonspecific aggregators, and inhibitors that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009, Vol.106 (23), p.9191-9196
Hauptverfasser:	Nerelius, C, Sandegren, A, Sargsyan, H, Raunak, R, Leijonmarck, H, Chatterjee, U, Fisahn, A, Imarisio, S, Lomas, D.A, Crowther, D.C, Strömberg, R, Johansson, J
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer disease central nervous system cytotoxicity Drosophila melanogaster humans ligands locomotion longevity neurodegenerative diseases polymerization
Online-Zugang:	Volltext
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