Glycogen synthase kinase 3β missplicing contributes to leukemia stem cell generation

Recent evidence suggests that a rare population of self-renewing cancer stem cells (CSC) is responsible for cancer progression and therapeutic resistance. Chronic myeloid leukemia (CML) represents an important paradigm for understanding the genetic and epigenetic events involved in CSC production. C...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009, Vol.106 (10), p.3925-3929
Hauptverfasser:	Abrahamsson, Annelie E, Geron, Ifat, Gotlib, Jason, Dao, Kim-Hien T, Barroga, Charlene F, Newton, Isabel G, Giles, Francis J, Durocher, Jeffrey, Creusot, Remi S, Karimi, Mobin, Jones, Carol, Zehnder, James L, Keating, Armand, Negrin, Robert S, Weissman, Irving L, Jamieson, Catriona H.M
Format:	Artikel
Sprache:	eng
Schlagworte:	complementary DNA cyclins epigenetics glycogen synthase kinases guanosine monophosphate hematopoietic stem cells mice myeloid leukemia prediction regulator genes tau-protein kinase
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