R-Spondin1 protects mice from chemotherapy or radiation-induced oral mucositis through the canonical Wnt/β-catenin pathway

R-Spondin1 (RSpo1) is a novel secreted protein that augments canonical Wnt/β-catenin signaling. We injected recombinant RSpo1 protein into transgenic Wnt reporter TOPGAL mice and have identified the oral mucosa as a target tissue for RSpo1. Administration of RSpo1 into normal mice triggered nuclear...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009, Vol.106 (7), p.2331-2336
Hauptverfasser:	Zhao, Jingsong, Kim, Kyung-Ah, De Vera, Josephine, Palencia, Servando, Wagle, Marie, Abo, Arie
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models cell proliferation dose response drug therapy epithelial cells fluorouracil genetically modified organisms irradiation keratinocytes mice mucosa protein secretion tongue X-radiation
Online-Zugang:	Volltext
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