Spatiotemporal expression and transcriptional perturbations by long noncoding RNAs in the mouse brain

Long noncoding RNAs (lncRNAs) have been implicated in numerous cellular processes including brain development. However, the in vivo expression dynamics and molecular pathways regulated by these loci are not well understood. Here, we leveraged a cohort of 13 lncRNA-null mutant mouse models to investi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2015-06, Vol.112 (22), p.6855-6862
Hauptverfasser:	Goff, Loyal A., Groff, Abigail F., Sauvageau, Martin, Trayes-Gibson, Zachary, Sanchez-Gomez, Diana B., Morse, Michael, Martin, Ryan D., Elcavage, Lara E., Liapis, Stephen C., Gonzalez-Celeiro, Meryem, Plana, Olivia, Li, Eric, Gerhardinger, Chiara, Tomassy, Giulio S., Arlotta, Paola, Rinn, John L.
Format:	Artikel
Sprache:	eng
Schlagworte:	adults animal models Animals Base Sequence beta-Galactosidase Biological Sciences brain Brain - growth & development Brain - metabolism Developmental biology Epigenetic Changes in the Developing Brain: Effects on Behavior Sackler Gene expression Gene Expression Profiling gene expression regulation Gene Expression Regulation - genetics Gene Expression Regulation - physiology Gene loci genes Immunohistochemistry loci Mice Mice, Knockout Microscopy, Confocal molecular dynamics Molecular Sequence Data mutants Mutation neurodevelopment Neurosciences non-coding RNA Ribonucleic acid RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Sequence Analysis, DNA space and time transcription (genetics) transcriptome
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