deoxynucleotide triphosphohydrolase SAMHD1 is a major regulator of DNA precursor pools in mammalian cells

Sterile alpha motif and HD-domain containing protein 1 (SAMHD1) is a triphosphohydrolase converting deoxynucleoside triphosphates (dNTPs) to deoxynucleosides. The enzyme was recently identified as a component of the human innate immune system that restricts HIV-1 infection by removing dNTPs required...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (35), p.14272-14277
Hauptverfasser:	Franzolin, Elisa, Pontarin, Giovanna, Rampazzo, Chiara, Miazzi, Cristina, Ferraro, Paola, Palumbo, Elisa, Reichard, Peter, Bianchi, Vera
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Cell Cycle Cell growth Cell Line Cell lines Cell Proliferation Cells Cultured cells Deoxyribonucleic acid DNA DNA Replication Enzymes Fibroblasts Gene expression regulation Gene Silencing HIV infections Human immunodeficiency virus 1 Humans innate immunity interphase Lungs Mammals metabolism Monomeric GTP-Binding Proteins - genetics Nucleic Acid Precursors - genetics ribonucleotide reductase RNA, Small Interfering roots SAM Domain and HD Domain-Containing Protein 1 Small interfering RNA T lymphocytes
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