Progressive hearing loss and gradual deterioration of sensory hair bundles in the ears of mice lacking the actin-binding protein Eps8L2

Mechanotransduction in the mammalian auditory system depends on mechanosensitive channels in the hair bundles that project from the apical surface of the sensory hair cells. Individual stereocilia within each bundle contain a core of tightly packed actin filaments, whose length is dynamically regula...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-08, Vol.110 (34), p.13898-13903
Hauptverfasser:	Furness, David N., Johnson, Stuart L., Manor, Uri, Rüttiger, Lukas, Tocchetti, Arianna, Offenhauser, Nina, Olt, Jennifer, Goodyear, Richard J., Vijayakumar, Sarath, Dai, Yuhai, Hackney, Carole M., Franz, Christoph, Di Fioreehi, Pier Paolo, Masetto, Sergio, Jones, Sherri M., Knipper, Marlies, Holley, Matthew C., Richardson, Guy P., Kachar, Bechara, Marcotti, Walter
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins adult development adults Analysis of Variance Animals Audiometry, Evoked Response Binding sites Biological Sciences Deafness ears Epidermal growth factor epidermal growth factor receptors Gene expression Gene expression regulation genes Hair Hair cells Hair Cells, Auditory - pathology Hair Cells, Auditory - physiology Hair Cells, Auditory - ultrastructure hearing disorders Hearing loss Hearing Loss - genetics mechanotransduction Mice Mice, Knockout microfilament proteins Microfilament Proteins - deficiency Microfilament Proteins - genetics Microfilaments Microscopy, Electron Morphology Patch-Clamp Techniques Proteins Sensory perception Stereocilia Vestibular hair cells
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