Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer’s disease-related pathology

Alzheimer’s disease (AD) is the most common cause of dementia worldwide. The pathogenesis of this neurodegenerative disease, currently without curative treatment, is associated with the accumulation of amyloid β (Aβ) in brain parenchyma and cerebral vasculature. AD patients are unable to clear this...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (5), p.1941-1946
Hauptverfasser:	Michaud, Jean-Philippe, Hallé, Maxime, Lampron, Antoine, Thériault, Peter, Préfontaine, Paul, Filali, Mohammed, Tribout-Jover, Pascale, Lanteigne, Anne-Marie, Jodoin, Rachel, Cluff, Christopher, Brichard, Vincent, Palmantier, Rémi, Pilorget, Anthony, Larocque, Daniel, Rivest, Serge
Format:	Artikel
Sprache:	eng
Schlagworte:	agonists Alzheimer disease Alzheimer Disease - metabolism Alzheimer Disease - pathology Alzheimer Disease - prevention & control Alzheimer's disease Alzheimers disease amyloid Amyloid beta-Protein Precursor - genetics Amyloid beta-Protein Precursor - metabolism Amyloids Animals Biological and medical sciences Biological Sciences Blotting, Western brain Brain - drug effects Brain - metabolism Brain - pathology Cell Line cognition Cytokines Cytokines - genetics Cytokines - metabolism Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Fundamental and applied biological sciences. Psychology Gene Expression - drug effects HEK293 Cells Humans immune system Immunity, Innate - drug effects immunomodulators Ligands lipid A Lipid A - administration & dosage Lipid A - analogs & derivatives Lipid A - therapeutic use Lipids Lipopolysaccharides - pharmacology Medical sciences Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - cytology Microglia - drug effects Microglia - metabolism Microscopy, Fluorescence Monocytes neurodegenerative diseases neuroglia Neurology parenchyma (animal tissue) Pathogenesis Pathology patients Peptides Phagocytosis Phagocytosis - drug effects Presenilin-1 - genetics Presenilin-1 - metabolism Reverse Transcriptase Polymerase Chain Reaction Rodents Toll-like receptor 4 Toll-Like Receptor 4 - agonists Toll-Like Receptor 4 - metabolism toxicity Vaccination Vertebrates: nervous system and sense organs
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