Bacterial quorum sensing, cooperativity, and anticipation of stationary-phase stress
Acyl-homoserine lactone–mediated quorum sensing (QS) regulates diverse activities in many species of Proteobacteria . QS-controlled genes commonly code for production of secreted or excreted public goods. The acyl-homoserine lactones are synthesized by members of the LuxI signal synthase family and...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS 2012-11, Vol.109 (48), p.19775-19780 |
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| creator | Goo, Eunhye Majerczyk, Charlotte D An, Jae Hyung Chandler, Josephine R Seo, Young-Su Ham, Hyeonheui Lim, Jae Yun Kim, Hongsup Lee, Bongsoo Jang, Moon Sun Greenberg, E. Peter Hwang, Ingyu |
| description | Acyl-homoserine lactone–mediated quorum sensing (QS) regulates diverse activities in many species of Proteobacteria . QS-controlled genes commonly code for production of secreted or excreted public goods. The acyl-homoserine lactones are synthesized by members of the LuxI signal synthase family and are detected by cognate members of the LuxR family of transcriptional regulators. QS affords a means of population density-dependent gene regulation. Control of public goods via QS provides a fitness benefit. Another potential role for QS is to anticipate overcrowding. As population density increases and stationary phase approaches, QS might induce functions important for existence in stationary phase. Here we provide evidence that in three related species of the genus Burkholderia QS allows individuals to anticipate and survive stationary-phase stress. Survival requires QS-dependent activation of cellular enzymes required for production of excreted oxalate, which serves to counteract ammonia-mediated alkaline toxicity during stationary phase. Our findings provide an example of QS serving as a means to anticipate stationary phase or life at the carrying capacity of a population by activating the expression of cytoplasmic enzymes, altering cellular metabolism, and producing a shared resource or public good, oxalate. |
| doi_str_mv | 10.1073/pnas.1218092109 |
| format | Article |
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Here we provide evidence that in three related species of the genus Burkholderia QS allows individuals to anticipate and survive stationary-phase stress. Survival requires QS-dependent activation of cellular enzymes required for production of excreted oxalate, which serves to counteract ammonia-mediated alkaline toxicity during stationary phase. 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Peter</creatorcontrib><creatorcontrib>Hwang, Ingyu</creatorcontrib><title>Bacterial quorum sensing, cooperativity, and anticipation of stationary-phase stress</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Acyl-homoserine lactone–mediated quorum sensing (QS) regulates diverse activities in many species of Proteobacteria . QS-controlled genes commonly code for production of secreted or excreted public goods. The acyl-homoserine lactones are synthesized by members of the LuxI signal synthase family and are detected by cognate members of the LuxR family of transcriptional regulators. QS affords a means of population density-dependent gene regulation. Control of public goods via QS provides a fitness benefit. Another potential role for QS is to anticipate overcrowding. As population density increases and stationary phase approaches, QS might induce functions important for existence in stationary phase. Here we provide evidence that in three related species of the genus Burkholderia QS allows individuals to anticipate and survive stationary-phase stress. Survival requires QS-dependent activation of cellular enzymes required for production of excreted oxalate, which serves to counteract ammonia-mediated alkaline toxicity during stationary phase. 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Peter</au><au>Hwang, Ingyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Bacterial quorum sensing, cooperativity, and anticipation of stationary-phase stress</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>2012-11-27</date><risdate>2012</risdate><volume>109</volume><issue>48</issue><spage>19775</spage><epage>19780</epage><pages>19775-19780</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Acyl-homoserine lactone–mediated quorum sensing (QS) regulates diverse activities in many species of Proteobacteria . QS-controlled genes commonly code for production of secreted or excreted public goods. The acyl-homoserine lactones are synthesized by members of the LuxI signal synthase family and are detected by cognate members of the LuxR family of transcriptional regulators. QS affords a means of population density-dependent gene regulation. Control of public goods via QS provides a fitness benefit. Another potential role for QS is to anticipate overcrowding. As population density increases and stationary phase approaches, QS might induce functions important for existence in stationary phase. Here we provide evidence that in three related species of the genus Burkholderia QS allows individuals to anticipate and survive stationary-phase stress. Survival requires QS-dependent activation of cellular enzymes required for production of excreted oxalate, which serves to counteract ammonia-mediated alkaline toxicity during stationary phase. 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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 2012-11, Vol.109 (48), p.19775-19780 |
| issn | 0027-8424 1091-6490 |
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| source | MEDLINE; Jstor Complete Legacy; PubMed Central; Alma/SFX Local Collection; Free Full-Text Journals in Chemistry |
| subjects | Ammonia Bacteria Biochemistry Biological Sciences Biosynthesis Burkholderia Burkholderia - genetics Burkholderia - physiology carrying capacity enzymes Gene expression Gene Expression Regulation, Bacterial Genes Genes, Bacterial Gram-negative bacteria Hydrogen-Ion Concentration lactones metabolism Mutation Oxalates Oxalates - metabolism population density Public goods public services and goods Quorum Sensing Signal transduction Southeast Asian culture Steepest descent method Survival analysis toxicity transcription factors |
| title | Bacterial quorum sensing, cooperativity, and anticipation of stationary-phase stress |
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