Mechanistic insights into editing-site specificity of ADARs

Adenosine deaminases that act on RNA (ADARs) deaminate adenosines in dsRNA to produce inosines. ADARs are essential in mammals and are particularly important in the nervous system. Altered levels of adenosine-to-inosine (A-to-I) editing are observed in several diseases. The extent to which an adenos...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-11, Vol.109 (48), p.E3295-E3304
Hauptverfasser:	Kuttan, Ashani, Bass, Brenda L
Format:	Artikel
Sprache:	eng
Schlagworte:	active sites adenosine Adenosine Deaminase - chemistry Adenosine Deaminase - physiology Amino Acid Sequence Amino acids Animals binding capacity Binding Sites Biological Sciences Catalytic Domain double-stranded RNA humans Mammals Models, Molecular Molecular Sequence Data Mutation Nervous system PNAS Plus Ribonucleic acid RNA RNA Editing RNA-Binding Proteins Sequence Homology, Amino Acid Yeast yeasts
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