Critical phosphoprotein elements that regulate polymerase architecture and function in vesicular stomatitis virus

The RNA-dependent RNA polymerase (RdRP) of nonsegmented negative-sense RNA viruses consists of a large catalytic protein (L) and a phosphoprotein cofactor (P). During infection, the RdRP replicates and transcribes the viral genome, which resides inside an oligomer of nucleocapsid protein (N -RNA). T...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-09, Vol.109 (36), p.14628-14633
Hauptverfasser:	Rahmeh, Amal A, Morin, Benjamin, Schenk, Andreas D, Liang, Bo, Heinrich, Bianca S, Brusic, Vesna, Walz, Thomas, Whelan, Sean P. J
Format:	Artikel
Sprache:	eng
Schlagworte:	Appendages Biochemistry Biological Sciences Blotting, Western Chromatography, Gel Chromatography, High Pressure Liquid Gene expression regulation genome Genomes Mass Spectrometry Messenger RNA Microscopy, Electron Models, Biological nucleocapsid proteins Nucleocapsid Proteins - metabolism Phosphoproteins Phosphoproteins - metabolism Phosphorylation Protein Conformation Proteins Ribonucleic acid RNA RNA polymerase RNA Replicase - metabolism RNA viruses RNA-directed RNA polymerase transcription (genetics) transposons Vesicular stomatitis Indiana virus Vesiculovirus Vesiculovirus - enzymology Viral Proteins - metabolism Viral Structural Proteins - metabolism Virus Replication - physiology Viruses
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