Metronidazole prevents reactivation of latent Mycobacterium tuberculosis infection in macaques

Targeting Mycobacterium tuberculosis bacilli in low-oxygen microenvironments, such as caseous granulomas, has been hypothesized to have the potential to shorten therapy for active tuberculosis (TB) and prevent reactivation of latent infection. We previously reported that upon low-dose M. tuberculosi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (35), p.14188-14193
Hauptverfasser:	Lin, Philana Ling, Dartois, Veronique, Johnston, Paul J, Janssen, Christopher, Via, Laura, Goodwin, Michael B, Klein, Edwin, Barry, Clifton E, Flynn, JoAnne L
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antibiotics Antiprotozoal Agents - pharmacokinetics Antiprotozoal Agents - pharmacology Antitubercular Agents - pharmacology Bacteria Biological Sciences chemoprevention Disease models Disease Models, Animal Disease prevention Dose-Response Relationship, Drug Drug Monitoring - methods Drug therapy Drug Therapy, Combination Granuloma Humans Hypoxia Infections Interferon-gamma - metabolism isoniazid Isoniazid - pharmacology Latent tuberculosis Latent Tuberculosis - drug therapy Lesions Macaca fascicularis metronidazole Metronidazole - pharmacokinetics Metronidazole - pharmacology Monkeys & apes Mycobacterium tuberculosis Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - growth & development neutralization Pulmonary tuberculosis rifampicin Secondary Prevention therapeutics Tuberculoma - drug therapy Tuberculosis Tuberculosis, Pulmonary - drug therapy tumor necrosis factors
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