Roco kinase structures give insights into the mechanism of Parkinson disease-related leucine-rich-repeat kinase 2 mutations

Mutations in human leucine-rich-repeat kinase 2 (LRRK2) have been found to be the most frequent cause of late-onset Parkinson disease. Here we show that Dictyostelium discoideum Roco4 is a suitable model to study the structural and biochemical characteristics of the LRRK2 kinase and can be used for...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-06, Vol.109 (26), p.10322-10327
Hauptverfasser:	Gilsbach, Bernd K, Ho, Franz Y, Vetter, Ingrid R, van Haastert, Peter J. M, Wittinghofer, Alfred, Kortholt, Arjan
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Bacteria Binding sites Biochemical mechanisms Biochemistry Biological Sciences Crystallography, X-Ray Dictyostelium discoideum Genetic mutation Humans Hydrogen bonds Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Models, Molecular Molecular Sequence Data mutants Mutation Optimization Parkinson disease Parkinson Disease - enzymology Parkinson Disease - genetics Parkinson's disease Phenotypes Phosphates Phosphorylation Protein Kinases - chemistry Protein Kinases - metabolism Protein-Serine-Threonine Kinases - chemistry Protein-Serine-Threonine Kinases - genetics Proteins Sequence Homology, Amino Acid
Online-Zugang:	Volltext
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