ᵐTc-labelled nanosystem as tumour imaging agent for SPECT and SPECT/CT modalities

We report the synthesis, in vitro and in vivo investigation of folate-targeted, biocompatible, biodegradable self-assembled nanoparticles radiolabelled with ⁹⁹ᵐTc, as potential new SPECT or SPECT/CT imaging agent. Nanoparticles with hydrodynamic size in the range of 75–200nm were prepared by self-as...

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Veröffentlicht in:	International journal of pharmaceutics 2013, Vol.449 (1-2), p.10-17
Hauptverfasser:	Polyák, András, Hajdu, István, Bodnár, Magdolna, Trencsényi, György, Pöstényi, Zita, Haász, Veronika, Jánoki, Gergely, Jánoki, Győző A, Balogh, Lajos, Borbély, János
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models biodegradability chitosan folic acid hepatoma hydrodynamics image analysis kidneys lungs nanoparticles polyglutamic acid radiolabeling rats receptors
Online-Zugang:	Volltext
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