New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A

Group VIA calcium-independent phospholipase A₂ (GVIA iPLA₂) has recently emerged as an important pharmaceutical target. Selective and potent GVIA iPLA₂ inhibitors can be used to study its role in various neurological disorders. In the current work, we explore the significance of the introduction of...

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Veröffentlicht in:	Bioorganic & medicinal chemistry 2013-09, Vol.21 (18), p.5823-5829
Hauptverfasser:	Magrioti, Victoria, Nikolaou, Aikaterini, Smyrniotou, Annetta, Shah, Ishita, Constantinou-Kokotou, Violetta, Dennis, Edward A, Kokotos, George
Format:	Artikel
Sprache:	eng
Schlagworte:	chemistry ketones nervous system diseases phospholipase A2
Online-Zugang:	Volltext
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