Involvement of O-glycosylation defining oncofetal fibronectin in epithelial-mesenchymal transition process

The process termed "epithelial–mesenchymal transition" (EMT) was originally discovered in ontogenic development, and has been shown to be one of the key steps in tumor cell progression and metastasis. Recently, we showed that the expression of some glycosphingolipids (GSLs) is down-regulat...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (43), p.17690-17695
Hauptverfasser:	Freire-de-Lima, Leonardo, Gelfenbeyn, Kirill, Ding, Yao, Mandel, Ulla, Clausen, Henrik, Handa, Kazuko, Hakomori, Sen-itiroh
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Animals Antibodies, Monoclonal Biological Sciences Blotting, Western Cadherins Cancer Cell Line Cell lines Cell motility cell movement Cells DNA Primers - genetics Epithelial Cells Epithelial-Mesenchymal Transition - physiology Epitopes fibronectins Fibronectins - metabolism Gene expression gene expression regulation Gene Expression Regulation, Neoplastic - physiology Gene Knockdown Techniques glycosphingolipids Glycosylation Hepatocytes Humans Mesenchymal stem cells Messenger RNA metastasis Mice N-Acetylgalactosaminyltransferases - genetics Polypeptide N-acetylgalactosaminyltransferase Prostate Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - metabolism RNA, Small Interfering - genetics Small interfering RNA threonine transforming growth factor beta Transforming Growth Factor beta - pharmacology Tumors
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