Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling

Fetal hypoxia is a common risk factor that has been associated with a range of CNS disorders including epilepsy, schizophrenia, and autism. Cellular and molecular mechanisms through which hypoxia may damage the developing brain are incompletely understood but are likely to involve disruption of the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-09, Vol.108 (37), p.15444-15449
Hauptverfasser:	Herr, Keira Joann, Herr, Deron R, Lee, Chang-Wook, Noguchi, Kyoko, Chun, Jerold
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autism bioactive properties Biological Sciences Botulinum toxin Brain Brain - embryology Brain - metabolism Brain - pathology Brain hypoxia Cell lines Cell migration Cell Movement Central nervous system Cerebral cortex Cerebral Cortex - embryology Cerebral Cortex - enzymology Cerebral Cortex - pathology Cerebral hemispheres Complications complications (disease) Cortex Data processing Epilepsy Female Fetal hypoxia Fetus - metabolism Fetus - pathology Fetuses G protein-coupled receptors G-Protein-Coupled Receptor Kinase 2 - antagonists & inhibitors G-Protein-Coupled Receptor Kinase 2 - metabolism Hypoxia Hypoxia - metabolism Hypoxia - pathology Injuries Lipids Lysophosphatidic acid receptors Lysophospholipids Mice Mitosis N-Cadherin Neural Stem Cells - metabolism Neural Stem Cells - pathology Neurons Proteins Receptors Receptors, Lysophosphatidic Acid - metabolism Risk factors Schizophrenia Signal Transduction stem cells
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