Crucial role of copper in detection of metal-coordinating odorants

Odorant receptors (ORs) in olfactory sensory neurons (OSNs) mediate detection of volatile odorants. Divalent sulfur compounds, such as thiols and thioethers, are extremely potent odorants. We identify a mouse OR, MOR244-3, robustly responding to (methylthio)methanethiol (MeSCH2SH; MTMT) in heterolog...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (9), p.3492-3497
Hauptverfasser:	Duan, Xufang, Block, Eric, Li, Zhen, Connelly, Timothy, Zhang, Jian, Huang, Zhimin, Su, Xubo, Pan, Yi, Wu, Lifang, Chi, Qiuyi, Thomas, Siji, Zhang, Shaozhong, Ma, Minghong, Matsunami, Hiroaki, Chen, Guo-Qiang, Zhuang, Hanyi
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Animals Biological Sciences Cadmium Cations - pharmacology Cells Chelating agents Chelating Agents - pharmacology Copper Copper - physiology Cyclic AMP - analysis Disulfides Dose-Response Relationship, Drug Electrophysiological recording Ethylenediamines - pharmacology Female Heavy metals Histidine Histidine - chemistry Humans Ions Ligands Male Metal ions Mice Mice, Inbred C57BL Models, Molecular Molecular Sequence Data Neurons odor compounds Odorant receptors Odorants Odors Olfaction Olfactory discrimination Olfactory perception Olfactory receptor neurons Olfactory Receptor Neurons - metabolism Patch-Clamp Techniques Physical Sciences Protein Conformation Protein Structure, Tertiary Receptors Receptors, Odorant - chemistry Receptors, Odorant - genetics Receptors, Odorant - physiology Rodents Semiochemicals Sensory neurons Sequence Alignment Sequence Homology, Amino Acid Sex Attractants - metabolism smell Structure-Activity Relationship Substrate Specificity Sulfhydryl Compounds - metabolism Sulfides Sulfides - metabolism sulfur sulfur compounds Sulfur Compounds - metabolism thioethers Thiols Transmembrane domains urine Volatiles
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