Motifs emerge from function in model gene regulatory networks

Gene regulatory networks allow the control of gene expression patterns in living cells. The study of network topology has revealed that certain subgraphs of interactions or "motifs" appear at anomalously high frequencies. We ask here whether this phenomenon may emerge because of the functi...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2011-10, Vol.108 (42), p.17263-17268
Hauptverfasser:	Burda, Z, Krzywicki, A, Martin, O. C, Zagorski, M
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding sites Cell cycle Condensed Matter Evolution Evolutionary genetics Gene expression gene frequency Gene Regulatory Networks Genes Genetic Association Studies Genotypes Government regulation Life Sciences Markov Chains Models, Genetic Monte Carlo Method Monte Carlo simulation Phenotypes Physical Sciences Physics Proteins regulator genes Statistical Mechanics statistics Topology Transcription factors Transcription Factors - genetics Transcription Factors - metabolism Transcription, Genetic Vegetal Biology
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