Epithelial transforming growth factor β-activated kinase 1 (TAK1) is activated through two independent mechanisms and regulates reactive oxygen species

Dysregulation in cellular redox systems results in accumulation of reactive oxygen species (ROS), which are causally associated with a number of disease conditions. Transforming growth factor β-activated kinase 1 (TAK1) is a signaling intermediate of innate immune signaling pathways and is criticall...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (9), p.3365-3370
Hauptverfasser:	Omori, Emily, Inagaki, Maiko, Mishina, Yuji, Matsumoto, Kunihiro, Ninomiya-Tsuji, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - deficiency Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - metabolism Animals Apoptosis binding proteins Biological Sciences cell death Enzyme Activation Epidermis Epidermis - enzymology Epithelial cells Epithelial Cells - enzymology Inflammation Intestinal mucosa Intestinal Mucosa - enzymology Intestines Keratinocytes Keratinocytes - enzymology MAP Kinase Kinase Kinases - metabolism Mice Mice, Knockout Oxidation-Reduction Oxidative Stress Phenotype Phosphatases Phosphorylation Protein Processing, Post-Translational Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Signal Transduction Skin TAK1 protein transforming growth factors
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