Mechanical stress-activated integrin α5β1 induces opening of connexin 43 hemichannels

The connexin 43 (Cx43) hemichannel (HC) in the mechanosensory osteocytes is a major portal for the release of factors responsible for the anabolic effects of mechanical loading on bone formation and remodeling. However, little is known about how the Cx43 molecule responds to mechanical stimulation l...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (9), p.3359-3364
Hauptverfasser:	Batra, Nidhi, Burra, Sirisha, Siller-Jackson, Arlene J, Gu, Sumin, Xia, Xuechun, Weber, Gregory F, DeSimone, Douglas, Bonewald, Lynda F, Lafer, Eileen M, Sprague, Eugene, Schwartz, Martin A, Jiang, Jean X
Format:	Artikel
Sprache:	eng
Schlagworte:	Androstadienes - pharmacology Animals Antibodies Biological Sciences bone formation Bones Cell Line Chromones - pharmacology Collagens Connexin 43 - metabolism Connexins Cultured cells Dyes Extracellular Matrix Proteins - metabolism Fibronectins - metabolism Fluid flow Fluid mechanics Immunomagnetic Separation Integrin alpha5beta1 - antagonists & inhibitors Integrin alpha5beta1 - physiology Integrins Mice Morpholines - pharmacology Osteocytes Osteocytes - metabolism phosphatidylinositol 3-kinase Phosphatidylinositol 3-Kinases - antagonists & inhibitors Phosphatidylinositol 3-Kinases - metabolism Protein Interaction Mapping RNA, Small Interfering - pharmacology Stress, Mechanical
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