ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila

To investigate the mechanistic basis for central nervous system (CNS) neurodegeneration in the disease ataxia–telangiectasia (A-T), we analyzed flies mutant for the causative gene A-T mutated (ATM). ATM encodes a protein kinase that functions to monitor the genomic integrity of cells and control cel...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-03, Vol.109 (11), p.E656-E664
Hauptverfasser:	Petersen, Andrew J, Rimkus, Stacey A, Wassarman, David A
Format:	Artikel
Sprache:	eng
Schlagworte:	adults Age Alzheimer's disease Amino acids Animals antagonists & inhibitors Apoptosis Ataxia telangiectasia Ataxia telangiectasia mutated protein Ataxia Telangiectasia Mutated Proteins Biological Sciences Brain Brain - pathology Cell cycle Cell Cycle Proteins Cell Cycle Proteins - antagonists & inhibitors Cell Cycle Proteins - metabolism Cell Death Cells Central nervous system Data processing DNA repair DNA-Binding Proteins DNA-Binding Proteins - antagonists & inhibitors DNA-Binding Proteins - metabolism Drosophila Drosophila melanogaster Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - immunology Drosophila Proteins Drosophila Proteins - antagonists & inhibitors Drosophila Proteins - metabolism enzymology Gene Knockdown Techniques genes genetics genomics Glial cells Immune response immunity Immunity, Innate Immunity, Innate - genetics Immunity, Innate - immunology immunology Inflammation Kinases Longevity metabolism Mobility mutants Mutation Nerve Degeneration Nerve Degeneration - enzymology Nerve Degeneration - genetics Nerve Degeneration - immunology Nerve Degeneration - pathology Neurodegeneration Neurodegenerative diseases neuroglia Neuroglia - enzymology Neuroglia - immunology Neuroglia - pathology neurons Neurons - enzymology Neurons - pathology pathology PNAS Plus protein kinases Protein Serine-Threonine Kinases Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - metabolism Temperature Tumor Suppressor Proteins Tumor Suppressor Proteins - antagonists & inhibitors Tumor Suppressor Proteins - metabolism Up-Regulation Up-Regulation - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!