Absence of hematopoietic tissue factor pathway inhibitor mitigates bleeding in mice with hemophilia

Tissue factor pathway inhibitor (TFPI) blocks thrombin generation via the extrinsic blood coagulation pathway. Because the severe bleeding in patients with hemophilia occurs from deficiency of intrinsic blood coagulation pathway factor VIII or IX, pharmacological agents that inactivate TFPI and, the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-03, Vol.109 (10), p.3927-3931
Hauptverfasser:	Maroney, Susan A, Cooley, Brian C, Ferrel, Josephine P, Bonesho, Catherine E, Nielsen, Lone V, Johansen, Peter B, Hermit, Mette B, Petersen, Lars C, Mast, Alan E
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animals Antibodies Biological Sciences Bleeding Blood Blood Coagulation Blood plasma Blood platelets Cells Coagulation Disease Models, Animal embryonic mortality Endothelial cells factor VIII Female fibrin Genetic Complementation Test Genotype Hematopoietic Stem Cells - cytology Hemophilia Hemophilia A - drug therapy Hemophilia A - genetics Hemophilia A - metabolism Hemorrhage Lipoproteins - genetics Lipoproteins - metabolism Liver - embryology Liver cells liver transplant Liver Transplantation Male Mice Mice, Inbred C57BL Mice, Transgenic patients Phenotype Platelets Rodents tail thrombin
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