diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus
A conventional diet enriched in retinyl acetate (vitam in A a ce tate; VAA) or in vivo administration of exogenous interleukin-2 (IL-2) can effectively annul the otherwise tolerogenic stimulus represented by (CBA x C57BL /10ScSn) F1 cells injected intraperitoneally into newborn CBA mice. On the basi...
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| Veröffentlicht in: | Proceedings of the Royal Society of London. Series B, Biological sciences Biological sciences, 1984-02, Vol.220 (1221), p.439-445 |
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| container_issue | 1221 |
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| container_title | Proceedings of the Royal Society of London. Series B, Biological sciences |
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| creator | Malkovský, M. Medawar, Peter Brian Hunt, Ruth Palmer, Lesley Doré, Caroline |
| description | A conventional diet enriched in retinyl acetate (vitam in A a ce tate; VAA) or in vivo administration of exogenous interleukin-2 (IL-2) can effectively annul the otherwise tolerogenic stimulus represented by (CBA x C57BL /10ScSn) F1 cells injected intraperitoneally into newborn CBA mice. On the basis of these data and results of others, we postulate that an antigenic stim ulus associated with a relative lack of IL-2 (or generally the lack of a ‘secondary stimulus’) can be tolerogenic rather than immunogenic. However, the tolerogenicity of the antigenic stimulus can be substantially reduced or even converted to sensitization (R. P. Cleveland & H. N. Claman, J. lmmun. 124, 474- 480, 1980), when the antigenic signal is appropriately associated with a concomitant or additional stimulus possibly mediated through IL-2. |
| doi_str_mv | 10.1098/rspb.1984.0012 |
| format | Article |
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On the basis of these data and results of others, we postulate that an antigenic stim ulus associated with a relative lack of IL-2 (or generally the lack of a ‘secondary stimulus’) can be tolerogenic rather than immunogenic. However, the tolerogenicity of the antigenic stimulus can be substantially reduced or even converted to sensitization (R. P. Cleveland & H. N. 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Series B, Biological sciences</title><addtitle>Proc. R. Soc. Lond. B</addtitle><addtitle>Proc. R. Soc. Lond. B</addtitle><description>A conventional diet enriched in retinyl acetate (vitam in A a ce tate; VAA) or in vivo administration of exogenous interleukin-2 (IL-2) can effectively annul the otherwise tolerogenic stimulus represented by (CBA x C57BL /10ScSn) F1 cells injected intraperitoneally into newborn CBA mice. On the basis of these data and results of others, we postulate that an antigenic stim ulus associated with a relative lack of IL-2 (or generally the lack of a ‘secondary stimulus’) can be tolerogenic rather than immunogenic. However, the tolerogenicity of the antigenic stimulus can be substantially reduced or even converted to sensitization (R. P. Cleveland & H. N. 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Psychology</subject><subject>Fundamental immunology</subject><subject>Graft Rejection - drug effects</subject><subject>Homologous transplantation</subject><subject>human nutrition</subject><subject>Immune tolerance</subject><subject>Immune Tolerance - drug effects</subject><subject>Immunobiology</subject><subject>Interleukin-2 - pharmacology</subject><subject>Male</subject><subject>Mice</subject><subject>Mice, Inbred Strains</subject><subject>Modulation of the immune response (stimulation, suppression)</subject><subject>Skin Transplantation</subject><subject>Spleen cells</subject><subject>T lymphocytes</subject><subject>Transplantation</subject><subject>Transplantation immunology</subject><subject>Transplantation, Homologous</subject><subject>Vitamin A</subject><subject>Vitamin A - analogs & derivatives</subject><subject>Vitamin A - pharmacology</subject><issn>0080-4649</issn><issn>0962-8452</issn><issn>0950-1193</issn><issn>2053-9193</issn><issn>1471-2954</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9ks1v0zAYxiMEGmVw5YCE8AFxS_FnEp-mMW2AtAm0Mq6W69ituzQOttNR_nqcpqpUIZaLFT-_93ntx2-WvUZwiiCvPvrQzaeIV3QKIcJPsgmGjOQccfI0m0BYwZwWlD_PXoSwgpAWnJOT7KRAFFNWTbJQWx2Bbr1VS10D24KNjXKd1nMglY4yauD8uL9xQNZJsiF6Ga1rgTNJido3ur-3bY6Bki1Qrh_2pIpAguga7d1Ct1aBEO26b_rwMntmZBP0q_16mt1dXf64-JJff_v89eL8OlesYDFXRiOseVXVipQUwRLXmBSqpKbEuKIGFsboeU1lxZQsKl2WlGg-pwVRNadIktPsw-jbefer1yGKtQ1KN41steuDqCBPH0MJnI6g8i4Er43ovF1LvxUIiiFlMaQshpTFkHIqeLt37udrXR_wfaxJf7_XZVCyMV62yoYDxhnEBeMJIyPm3TYF4VR6i61Yud636ff_zcNjVbez758QZ3yDMbQIYyRgRVJ6aRSw-GO7nd0AiAQIG0KvxQ47bvNv1zdj11WIzh-uQljJyiTmo5hGQ_8-iNLfi6IkJRM_k80Nv7kt6YyLq8SfjfzSLpYP1mtxdJdda-XSFLVxd8rd-SjhwvRNI7raJAf0qIPbdj7Mj4pTzbuxxkgn5MKnF7mbYYgIxIwSkgbnL8VeBmc</recordid><startdate>19840222</startdate><enddate>19840222</enddate><creator>Malkovský, M.</creator><creator>Medawar, Peter Brian</creator><creator>Hunt, Ruth</creator><creator>Palmer, Lesley</creator><creator>Doré, Caroline</creator><general>The Royal Society</general><general>Royal Society of London</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19840222</creationdate><title>diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus</title><author>Malkovský, M. ; Medawar, Peter Brian ; Hunt, Ruth ; Palmer, Lesley ; Doré, Caroline</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c565t-cfe12e988dc3741072d236c74f72284f06ffebd4a85ca68e7743e9b463cd941a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Acetates</topic><topic>Animals</topic><topic>Animals, Newborn</topic><topic>Antigens - administration & dosage</topic><topic>Biological and medical sciences</topic><topic>Cyclosporins</topic><topic>Diet</topic><topic>diet-related diseases</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Fundamental immunology</topic><topic>Graft Rejection - drug effects</topic><topic>Homologous transplantation</topic><topic>human nutrition</topic><topic>Immune tolerance</topic><topic>Immune Tolerance - drug effects</topic><topic>Immunobiology</topic><topic>Interleukin-2 - pharmacology</topic><topic>Male</topic><topic>Mice</topic><topic>Mice, Inbred Strains</topic><topic>Modulation of the immune response (stimulation, suppression)</topic><topic>Skin Transplantation</topic><topic>Spleen cells</topic><topic>T lymphocytes</topic><topic>Transplantation</topic><topic>Transplantation immunology</topic><topic>Transplantation, Homologous</topic><topic>Vitamin A</topic><topic>Vitamin A - analogs & derivatives</topic><topic>Vitamin A - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Malkovský, M.</creatorcontrib><creatorcontrib>Medawar, Peter Brian</creatorcontrib><creatorcontrib>Hunt, Ruth</creatorcontrib><creatorcontrib>Palmer, Lesley</creatorcontrib><creatorcontrib>Doré, Caroline</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Malkovský, M.</au><au>Medawar, Peter Brian</au><au>Hunt, Ruth</au><au>Palmer, Lesley</au><au>Doré, Caroline</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus</atitle><jtitle>Proceedings of the Royal Society of London. Series B, Biological sciences</jtitle><stitle>Proc. R. Soc. Lond. B</stitle><addtitle>Proc. R. Soc. Lond. B</addtitle><date>1984-02-22</date><risdate>1984</risdate><volume>220</volume><issue>1221</issue><spage>439</spage><epage>445</epage><pages>439-445</pages><issn>0080-4649</issn><issn>0962-8452</issn><issn>0950-1193</issn><eissn>2053-9193</eissn><eissn>1471-2954</eissn><coden>PRLBA4</coden><abstract>A conventional diet enriched in retinyl acetate (vitam in A a ce tate; VAA) or in vivo administration of exogenous interleukin-2 (IL-2) can effectively annul the otherwise tolerogenic stimulus represented by (CBA x C57BL /10ScSn) F1 cells injected intraperitoneally into newborn CBA mice. On the basis of these data and results of others, we postulate that an antigenic stim ulus associated with a relative lack of IL-2 (or generally the lack of a ‘secondary stimulus’) can be tolerogenic rather than immunogenic. However, the tolerogenicity of the antigenic stimulus can be substantially reduced or even converted to sensitization (R. P. Cleveland & H. N. 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| identifier | ISSN: 0080-4649 |
| ispartof | Proceedings of the Royal Society of London. Series B, Biological sciences, 1984-02, Vol.220 (1221), p.439-445 |
| issn | 0080-4649 0962-8452 0950-1193 2053-9193 1471-2954 |
| language | eng |
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| source | MEDLINE; Jstor Complete Legacy |
| subjects | Acetates Animals Animals, Newborn Antigens - administration & dosage Biological and medical sciences Cyclosporins Diet diet-related diseases Female Fundamental and applied biological sciences. Psychology Fundamental immunology Graft Rejection - drug effects Homologous transplantation human nutrition Immune tolerance Immune Tolerance - drug effects Immunobiology Interleukin-2 - pharmacology Male Mice Mice, Inbred Strains Modulation of the immune response (stimulation, suppression) Skin Transplantation Spleen cells T lymphocytes Transplantation Transplantation immunology Transplantation, Homologous Vitamin A Vitamin A - analogs & derivatives Vitamin A - pharmacology |
| title | diet enriched in vitamin A acetate or in vivo administration of interleukin-2 can counteract a tolerogenic stimulus |
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