Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection

Streptococcus pneumoniae is a major cause of pneumonia in infants and the elderly. Innate defenses are essential to the control of pneumococcal infections, and deficient responses can trigger disease in susceptible individuals. Here we showed that flagellin can locally activate innate immunity and t...

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Veröffentlicht in:	Infection and Immunity 2010-10, Vol.78 (10), p.4226-4233
Hauptverfasser:	Muñoz, Natalia, Van Maele, Laurye, Marqués, Juan M, Rial, Analía, Sirard, Jean-Claude, Chabalgoity, José A
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intranasal Animals B-Lymphocytes Bacterial diseases Bacterial Vaccines - administration & dosage Bacterial Vaccines - immunology Biological and medical sciences Bronchoalveolar Lavage Bronchoalveolar Lavage Fluid Chemokines Cytokines Female Flagellin Flagellin - genetics Flagellin - immunology Fundamental and applied biological sciences. Psychology Human bacterial diseases Human health and pathology Immunity, Innate Immunity, Mucosal Immunology Infectious diseases Inflammation Life Sciences Lung Lung - cytology Lung - microbiology Lung - pathology Medical sciences Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Mice, SCID Microbial Immunity and Vaccines Microbiology Mucosal Tracts Infections Mutation Nasal Mucosa - immunology Neutrophil Neutrophils - physiology Pneumonia, Pneumococcal - immunology Pneumonia, Pneumococcal - prevention & control Signal Transduction Staphylococcal infections, streptococcal infections, pneumococcal infections Streptococcus pneumoniae Streptococcus pneumoniae - genetics Streptococcus pneumoniae - immunology T-Lymphocytes Toll-Like Receptor 5 Toll-Like Receptor 5 - physiology
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