Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils
The efficacy of target-released butyric acid, medium-chain fatty acids (C6 to C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated. The minimal inhibitory concentr...
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| Veröffentlicht in: | Avian pathology 2010-04, Vol.39 (2), p.117-121 |
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| creator | Timbermont, L Lanckriet, A Dewulf, J Nollet, N Schwarzer, K Haesebrouck, F Ducatelle, R Immerseel, F. Van |
| description | The efficacy of target-released butyric acid, medium-chain fatty acids (C6 to C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated. The minimal inhibitory concentrations of the different additives were determined in vitro, showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of Clostridium perfringens. The in vivo effects were studied in two trials in an experimental necrotic enteritis model in broiler chickens. In the first trial, four groups of chickens were fed a diet supplemented with butyric acid, with essential oils, with butyric acid in combination with medium-chain fatty acids, or with butyric acid in combination with medium-chain fatty acids and essential oils. In all groups except for the group receiving only butyric acid, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. In the second trial the same products were tested but at a higher concentration. An additional group was fed a diet supplemented with only medium-chain fatty acids. In all groups except for that receiving butyric acid in combination with medium-chain fatty acids and essential oils, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. These results suggest that butyric acid, medium-chain fatty acids and/or essential oils may contribute to the prevention of necrotic enteritis in broilers. |
| doi_str_mv | 10.1080/03079451003610586 |
| format | Article |
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Van</creator><creatorcontrib>Timbermont, L ; Lanckriet, A ; Dewulf, J ; Nollet, N ; Schwarzer, K ; Haesebrouck, F ; Ducatelle, R ; Immerseel, F. Van</creatorcontrib><description>The efficacy of target-released butyric acid, medium-chain fatty acids (C6 to C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated. The minimal inhibitory concentrations of the different additives were determined in vitro, showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of Clostridium perfringens. The in vivo effects were studied in two trials in an experimental necrotic enteritis model in broiler chickens. In the first trial, four groups of chickens were fed a diet supplemented with butyric acid, with essential oils, with butyric acid in combination with medium-chain fatty acids, or with butyric acid in combination with medium-chain fatty acids and essential oils. In all groups except for the group receiving only butyric acid, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. In the second trial the same products were tested but at a higher concentration. An additional group was fed a diet supplemented with only medium-chain fatty acids. In all groups except for that receiving butyric acid in combination with medium-chain fatty acids and essential oils, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. These results suggest that butyric acid, medium-chain fatty acids and/or essential oils may contribute to the prevention of necrotic enteritis in broilers.</description><identifier>ISSN: 0307-9457</identifier><identifier>EISSN: 1465-3338</identifier><identifier>DOI: 10.1080/03079451003610586</identifier><identifier>PMID: 20390546</identifier><language>eng</language><publisher>England: Taylor & Francis Group</publisher><subject><![CDATA[Animal diseases ; animal pathogenic bacteria ; Animals ; Bacteria ; biological control ; broiler chickens ; broiler feeding ; butyric acid ; Butyric Acid - administration & dosage ; Chickens ; cinnamaldehyde ; clinical examination ; Clostridium ; Clostridium Infections - drug therapy ; Clostridium Infections - pathology ; Clostridium Infections - prevention & control ; Clostridium perfringens ; Clostridium perfringens - drug effects ; disease course ; Disease Models, Animal ; dosage ; dose response ; Drug Compounding ; Enteritis - drug therapy ; Enteritis - pathology ; Enteritis - prevention & control ; essential oil of Eucalyptus ; essential oils ; Eucalyptus ; Fatty acids ; feed supplements ; food animals ; herbal medicines ; medium chain fatty acids ; microencapsulation ; Necrosis - prevention & control ; necrotic enteritis ; Oils, Volatile - administration & dosage ; Poultry ; Poultry Diseases - drug therapy ; Poultry Diseases - pathology ; Poultry Diseases - prevention & control ; Sugar ; thymol]]></subject><ispartof>Avian pathology, 2010-04, Vol.39 (2), p.117-121</ispartof><rights>Copyright Houghton Trust Ltd 2010</rights><rights>Copyright Taylor & Francis Ltd. Apr 2010</rights><rights>Distributed under a Creative Commons Attribution 4.0 International License</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-8023f5b349f5754a823267bfee3b031c13c2c530d89d21215b85238f17e680003</citedby><cites>FETCH-LOGICAL-c518t-8023f5b349f5754a823267bfee3b031c13c2c530d89d21215b85238f17e680003</cites><orcidid>0000-0003-0455-3350</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20390546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://hal.science/hal-00584275$$DView record in HAL$$Hfree_for_read</backlink></links><search><creatorcontrib>Timbermont, L</creatorcontrib><creatorcontrib>Lanckriet, A</creatorcontrib><creatorcontrib>Dewulf, J</creatorcontrib><creatorcontrib>Nollet, N</creatorcontrib><creatorcontrib>Schwarzer, K</creatorcontrib><creatorcontrib>Haesebrouck, F</creatorcontrib><creatorcontrib>Ducatelle, R</creatorcontrib><creatorcontrib>Immerseel, F. Van</creatorcontrib><title>Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils</title><title>Avian pathology</title><addtitle>Avian Pathol</addtitle><description>The efficacy of target-released butyric acid, medium-chain fatty acids (C6 to C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated. The minimal inhibitory concentrations of the different additives were determined in vitro, showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of Clostridium perfringens. The in vivo effects were studied in two trials in an experimental necrotic enteritis model in broiler chickens. In the first trial, four groups of chickens were fed a diet supplemented with butyric acid, with essential oils, with butyric acid in combination with medium-chain fatty acids, or with butyric acid in combination with medium-chain fatty acids and essential oils. In all groups except for the group receiving only butyric acid, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. In the second trial the same products were tested but at a higher concentration. An additional group was fed a diet supplemented with only medium-chain fatty acids. In all groups except for that receiving butyric acid in combination with medium-chain fatty acids and essential oils, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. These results suggest that butyric acid, medium-chain fatty acids and/or essential oils may contribute to the prevention of necrotic enteritis in broilers.</description><subject>Animal diseases</subject><subject>animal pathogenic bacteria</subject><subject>Animals</subject><subject>Bacteria</subject><subject>biological control</subject><subject>broiler chickens</subject><subject>broiler feeding</subject><subject>butyric acid</subject><subject>Butyric Acid - administration & dosage</subject><subject>Chickens</subject><subject>cinnamaldehyde</subject><subject>clinical examination</subject><subject>Clostridium</subject><subject>Clostridium Infections - drug therapy</subject><subject>Clostridium Infections - pathology</subject><subject>Clostridium Infections - prevention & control</subject><subject>Clostridium perfringens</subject><subject>Clostridium perfringens - drug effects</subject><subject>disease course</subject><subject>Disease Models, Animal</subject><subject>dosage</subject><subject>dose response</subject><subject>Drug Compounding</subject><subject>Enteritis - drug therapy</subject><subject>Enteritis - pathology</subject><subject>Enteritis - prevention & control</subject><subject>essential oil of Eucalyptus</subject><subject>essential oils</subject><subject>Eucalyptus</subject><subject>Fatty acids</subject><subject>feed supplements</subject><subject>food animals</subject><subject>herbal medicines</subject><subject>medium chain fatty acids</subject><subject>microencapsulation</subject><subject>Necrosis - prevention & control</subject><subject>necrotic enteritis</subject><subject>Oils, Volatile - administration & dosage</subject><subject>Poultry</subject><subject>Poultry Diseases - drug therapy</subject><subject>Poultry Diseases - pathology</subject><subject>Poultry Diseases - prevention & control</subject><subject>Sugar</subject><subject>thymol</subject><issn>0307-9457</issn><issn>1465-3338</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc2OFCEUhStG47SjD-BGiRtjYumFC_WTuJl01DHpxIXOmlBV0DKhoQVqtB7Bt5a2x1k4ibOCwHcOl3Oq6imFNxQ6eAsIbc8FBcCGguiae9WK8kbUiNjdr1aH-7oA7Un1KKVLAGiEYA-rEwbYg-DNqvq1Dj7H4EgwZO1CytFOdt6RvY4mWr_VPtXWT_OoJ-L1GEO2I9E-62izTcR6MsRgnY6JDAvJKm51rqN2WqWiGOa8xCJQo51eE6NyXv7sE1F-Ijql4mRVedy69Lh6YJRL-sn1elpdfHj_dX1ebz5__LQ-29SjoF2uO2BoxIC8N6IVXHUMWdMORmscAOlIcWSjQJi6fmKUUTF0gmFnaKubriSAp9Wro-835eQ-2p2KiwzKyvOzjTycQUmSs1Zc0cK-PLL7GL7POmW5s2nUzimvw5xky0XDGe_Z3SRig6znTSFf_ENehjn68mXJgLfIGBzs6BEqiacUtbmZlII8dC9vdV80z66N52GnpxvF37IL0B4B602IO_UjRDfJrBYXStnKjzbdtpX5Zy7Kd3cq8X-TPT_KjQpSbWOhL74woAi0K3Nhi78Bg03Wyg</recordid><startdate>201004</startdate><enddate>201004</enddate><creator>Timbermont, L</creator><creator>Lanckriet, A</creator><creator>Dewulf, J</creator><creator>Nollet, N</creator><creator>Schwarzer, K</creator><creator>Haesebrouck, F</creator><creator>Ducatelle, R</creator><creator>Immerseel, F. 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Van</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils</atitle><jtitle>Avian pathology</jtitle><addtitle>Avian Pathol</addtitle><date>2010-04</date><risdate>2010</risdate><volume>39</volume><issue>2</issue><spage>117</spage><epage>121</epage><pages>117-121</pages><issn>0307-9457</issn><eissn>1465-3338</eissn><abstract>The efficacy of target-released butyric acid, medium-chain fatty acids (C6 to C12 but mainly lauric acid) and essential oils (thymol, cinnamaldehyde, essential oil of eucalyptus) micro-encapsulated in a poly-sugar matrix to control necrotic enteritis was investigated. The minimal inhibitory concentrations of the different additives were determined in vitro, showing that lauric acid, thymol, and cinnamaldehyde are very effective in inhibiting the growth of Clostridium perfringens. The in vivo effects were studied in two trials in an experimental necrotic enteritis model in broiler chickens. In the first trial, four groups of chickens were fed a diet supplemented with butyric acid, with essential oils, with butyric acid in combination with medium-chain fatty acids, or with butyric acid in combination with medium-chain fatty acids and essential oils. In all groups except for the group receiving only butyric acid, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. In the second trial the same products were tested but at a higher concentration. An additional group was fed a diet supplemented with only medium-chain fatty acids. In all groups except for that receiving butyric acid in combination with medium-chain fatty acids and essential oils, a significant decrease in the number of birds with necrotic lesions was found compared with the infected, untreated control group. These results suggest that butyric acid, medium-chain fatty acids and/or essential oils may contribute to the prevention of necrotic enteritis in broilers.</abstract><cop>England</cop><pub>Taylor & Francis Group</pub><pmid>20390546</pmid><doi>10.1080/03079451003610586</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0003-0455-3350</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Avian pathology, 2010-04, Vol.39 (2), p.117-121 |
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| language | eng |
| recordid | cdi_fao_agris_US201301846337 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Animal diseases animal pathogenic bacteria Animals Bacteria biological control broiler chickens broiler feeding butyric acid Butyric Acid - administration & dosage Chickens cinnamaldehyde clinical examination Clostridium Clostridium Infections - drug therapy Clostridium Infections - pathology Clostridium Infections - prevention & control Clostridium perfringens Clostridium perfringens - drug effects disease course Disease Models, Animal dosage dose response Drug Compounding Enteritis - drug therapy Enteritis - pathology Enteritis - prevention & control essential oil of Eucalyptus essential oils Eucalyptus Fatty acids feed supplements food animals herbal medicines medium chain fatty acids microencapsulation Necrosis - prevention & control necrotic enteritis Oils, Volatile - administration & dosage Poultry Poultry Diseases - drug therapy Poultry Diseases - pathology Poultry Diseases - prevention & control Sugar thymol |
| title | Control of Clostridium perfringens-induced necrotic enteritis in broilers by target-released butyric acid, fatty acids and essential oils |
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