Plant homologs of the Plasmodium falciparum chloroquine-resistance transporter, PfCRT, are required for glutathione homeostasis and stress responses

In Arabidopsis thaliana, biosynthesis of the essential thiol antioxidant, glutathione (GSH), is plastid-regulated, but many GSH functions, including heavy metal detoxification and plant defense activation, depend on cytosolic GSH. This finding suggests that plastid and cytosol thiol pools are closel...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-02, Vol.107 (5), p.2331-2336
Hauptverfasser:	Maughan, Spencer C, Pasternak, Maciej, Cairns, Narelle, Kiddle, Guy, Brach, Thorsten, Jarvis, Renee, Haas, Florian, Nieuwland, Jeroen, Lim, Benson, Müller, Christopher, Salcedo-Sora, Enrique, Kruse, Cordula, Orsel, Mathilde, Hell, Rüdiger, Miller, Anthony J, Bray, Patrick, Foyer, Christine H, Murray, James A.H, Meyer, Andreas J, Cobbett, Christopher S
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimalarials - pharmacology Arabidopsis - genetics Arabidopsis - metabolism Arabidopsis Proteins - genetics Arabidopsis Proteins - metabolism Arabidopsis thaliana Biological Sciences Biosynthesis cadmium Cadmium - pharmacology Chloroplasts Chloroquine - pharmacology Cytosol disease reservoirs Drug Resistance Female Flowers & plants Gene expression Genes, Plant Genotype & phenotype glutathione Glutathione - metabolism Homeostasis In Vitro Techniques Infections Life Sciences Membrane Transport Proteins - genetics Membrane Transport Proteins - metabolism Models, Biological mutants Mutation Oocytes Oocytes - metabolism Parasitic protozoa Peptides phenotype Phytophthora Phytophthora brassicae phytotoxicity Plant cells Plants Plants, Genetically Modified Plasmodium falciparum - drug effects Plasmodium falciparum - genetics Plasmodium falciparum - metabolism Plasmodium falciparum chloroquine-resistance transporter Plastids Proteins Protozoan Proteins - genetics Protozoan Proteins - metabolism Recombinant Proteins - genetics Recombinant Proteins - metabolism redox potential roots Stress, Physiological Thiols transporters Xenopus
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