Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China
The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly...
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| Veröffentlicht in: | Journal of Clinical Microbiology 2010-02, Vol.48 (2), p.357-362 |
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| creator | Yuan, Quan Ou, Shan-Hai Chen, Chang-Rong Ge, Sheng-Xiang Pei, Bin Chen, Qing-Rui Yan, Qiang Lin, Yong-Cai Ni, Hong-Ying Huang, Cheng-Hao Yeo, Anthony E.T Shih, James W.K Zhang, Jun Xia, Ning-Shao |
| description | The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg⁺) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg⁺ donors, carriers with OBIs versus HBsAg⁺ asymptomatic carriers, and carriers with OBIs versus HBsAg⁺ chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections. |
| doi_str_mv | 10.1128/JCM.01781-09 |
| format | Article |
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The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg⁺) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg⁺ donors, carriers with OBIs versus HBsAg⁺ asymptomatic carriers, and carriers with OBIs versus HBsAg⁺ chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.</description><identifier>ISSN: 0095-1137</identifier><identifier>EISSN: 1098-660X</identifier><identifier>DOI: 10.1128/JCM.01781-09</identifier><identifier>PMID: 19940057</identifier><identifier>CODEN: JCMIDW</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>Adult ; Amino Acid Sequence ; Amino Acid Substitution ; Biological and medical sciences ; Blood Donors ; Carrier State - virology ; China ; DNA, Viral - genetics ; Female ; Fundamental and applied biological sciences. Psychology ; Genotype ; Hepatitis B - virology ; Hepatitis B Surface Antigens - genetics ; Hepatitis B virus ; Hepatitis B virus - genetics ; Hepatitis B virus - isolation & purification ; Hepatitis B, Chronic - virology ; Humans ; Male ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mutation, Missense ; Sequence Analysis, DNA ; Virology ; Young Adult</subject><ispartof>Journal of Clinical Microbiology, 2010-02, Vol.48 (2), p.357-362</ispartof><rights>2015 INIST-CNRS</rights><rights>Copyright © 2010, American Society for Microbiology 2010</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c559t-c2ecb9d35ebbb7edc12fcebecaa4dc471fdad0e051adc33d2ad7e7470efb45093</citedby><cites>FETCH-LOGICAL-c559t-c2ecb9d35ebbb7edc12fcebecaa4dc471fdad0e051adc33d2ad7e7470efb45093</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815617/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815617/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3175,3176,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22774568$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19940057$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Quan</creatorcontrib><creatorcontrib>Ou, Shan-Hai</creatorcontrib><creatorcontrib>Chen, Chang-Rong</creatorcontrib><creatorcontrib>Ge, Sheng-Xiang</creatorcontrib><creatorcontrib>Pei, Bin</creatorcontrib><creatorcontrib>Chen, Qing-Rui</creatorcontrib><creatorcontrib>Yan, Qiang</creatorcontrib><creatorcontrib>Lin, Yong-Cai</creatorcontrib><creatorcontrib>Ni, Hong-Ying</creatorcontrib><creatorcontrib>Huang, Cheng-Hao</creatorcontrib><creatorcontrib>Yeo, Anthony E.T</creatorcontrib><creatorcontrib>Shih, James W.K</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Xia, Ning-Shao</creatorcontrib><title>Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China</title><title>Journal of Clinical Microbiology</title><addtitle>J Clin Microbiol</addtitle><description>The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg⁺) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg⁺ donors, carriers with OBIs versus HBsAg⁺ asymptomatic carriers, and carriers with OBIs versus HBsAg⁺ chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.</description><subject>Adult</subject><subject>Amino Acid Sequence</subject><subject>Amino Acid Substitution</subject><subject>Biological and medical sciences</subject><subject>Blood Donors</subject><subject>Carrier State - virology</subject><subject>China</subject><subject>DNA, Viral - genetics</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Genotype</subject><subject>Hepatitis B - virology</subject><subject>Hepatitis B Surface Antigens - genetics</subject><subject>Hepatitis B virus</subject><subject>Hepatitis B virus - genetics</subject><subject>Hepatitis B virus - isolation & purification</subject><subject>Hepatitis B, Chronic - virology</subject><subject>Humans</subject><subject>Male</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Molecular Sequence Data</subject><subject>Mutation, Missense</subject><subject>Sequence Analysis, DNA</subject><subject>Virology</subject><subject>Young Adult</subject><issn>0095-1137</issn><issn>1098-660X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkU1v1DAQhi0Eokvhxhl8gRMpHideJ5dKdPkoqFUPpQhxsSbOZNdVEi-2A-LfY3ZXBU4-zDOPX83L2FMQJwCyfv1pdXkiQNdQiOYeW4Bo6mK5FF_vs4UQjSoASn3EHsV4KwRUlVIP2RE0TSWE0gv27dIPZOcBA19tMKBNFFxMzkbue35l8yjxc9picslFfsa_uDBH3gc_8rPB-46_9ZMPkbuJX_s5bQhjyio34WP2oMch0pPDe8xu3r_7vDovLq4-fFy9uSisUk0qrCTbNl2pqG1bTZ0F2VtqySJWna009B12goQC7GxZdhI7TbrSgvq2UqIpj9np3rud2zHv05QCDmYb3Ijhl_HozP-TyW3M2v8wsga1BJ0FLw-C4L_PFJMZXbQ0DDiRn6ORoPLpFGTw1R60wccYqL_7BIT5U4bJZZhdGWYX7Nm_wf7Ch-tn4MUBwGhx6ANO1sU7TkqtK7WsM8f33MatNz9dIINxNLd2NFVtpCl3qud7pEdvcJ07NDfXUkCZ0zRa6rr8Db8GqTc</recordid><startdate>20100201</startdate><enddate>20100201</enddate><creator>Yuan, Quan</creator><creator>Ou, Shan-Hai</creator><creator>Chen, Chang-Rong</creator><creator>Ge, Sheng-Xiang</creator><creator>Pei, Bin</creator><creator>Chen, Qing-Rui</creator><creator>Yan, Qiang</creator><creator>Lin, Yong-Cai</creator><creator>Ni, Hong-Ying</creator><creator>Huang, Cheng-Hao</creator><creator>Yeo, Anthony E.T</creator><creator>Shih, James W.K</creator><creator>Zhang, Jun</creator><creator>Xia, Ning-Shao</creator><general>American Society for Microbiology</general><general>American Society for Microbiology (ASM)</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U9</scope><scope>H94</scope><scope>5PM</scope></search><sort><creationdate>20100201</creationdate><title>Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China</title><author>Yuan, Quan ; Ou, Shan-Hai ; Chen, Chang-Rong ; Ge, Sheng-Xiang ; Pei, Bin ; Chen, Qing-Rui ; Yan, Qiang ; Lin, Yong-Cai ; Ni, Hong-Ying ; Huang, Cheng-Hao ; Yeo, Anthony E.T ; Shih, James W.K ; Zhang, Jun ; Xia, Ning-Shao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c559t-c2ecb9d35ebbb7edc12fcebecaa4dc471fdad0e051adc33d2ad7e7470efb45093</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Adult</topic><topic>Amino Acid Sequence</topic><topic>Amino Acid Substitution</topic><topic>Biological and medical sciences</topic><topic>Blood Donors</topic><topic>Carrier State - virology</topic><topic>China</topic><topic>DNA, Viral - genetics</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Genotype</topic><topic>Hepatitis B - virology</topic><topic>Hepatitis B Surface Antigens - genetics</topic><topic>Hepatitis B virus</topic><topic>Hepatitis B virus - genetics</topic><topic>Hepatitis B virus - isolation & purification</topic><topic>Hepatitis B, Chronic - virology</topic><topic>Humans</topic><topic>Male</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Molecular Sequence Data</topic><topic>Mutation, Missense</topic><topic>Sequence Analysis, DNA</topic><topic>Virology</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yuan, Quan</creatorcontrib><creatorcontrib>Ou, Shan-Hai</creatorcontrib><creatorcontrib>Chen, Chang-Rong</creatorcontrib><creatorcontrib>Ge, Sheng-Xiang</creatorcontrib><creatorcontrib>Pei, Bin</creatorcontrib><creatorcontrib>Chen, Qing-Rui</creatorcontrib><creatorcontrib>Yan, Qiang</creatorcontrib><creatorcontrib>Lin, Yong-Cai</creatorcontrib><creatorcontrib>Ni, Hong-Ying</creatorcontrib><creatorcontrib>Huang, Cheng-Hao</creatorcontrib><creatorcontrib>Yeo, Anthony E.T</creatorcontrib><creatorcontrib>Shih, James W.K</creatorcontrib><creatorcontrib>Zhang, Jun</creatorcontrib><creatorcontrib>Xia, Ning-Shao</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of Clinical Microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yuan, Quan</au><au>Ou, Shan-Hai</au><au>Chen, Chang-Rong</au><au>Ge, Sheng-Xiang</au><au>Pei, Bin</au><au>Chen, Qing-Rui</au><au>Yan, Qiang</au><au>Lin, Yong-Cai</au><au>Ni, Hong-Ying</au><au>Huang, Cheng-Hao</au><au>Yeo, Anthony E.T</au><au>Shih, James W.K</au><au>Zhang, Jun</au><au>Xia, Ning-Shao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China</atitle><jtitle>Journal of Clinical Microbiology</jtitle><addtitle>J Clin Microbiol</addtitle><date>2010-02-01</date><risdate>2010</risdate><volume>48</volume><issue>2</issue><spage>357</spage><epage>362</epage><pages>357-362</pages><issn>0095-1137</issn><eissn>1098-660X</eissn><coden>JCMIDW</coden><abstract>The characteristics of 30 carriers with occult hepatitis B virus (HBV) infection (OBI) were compared with those of 30 individuals diagnosed as being HBV carriers at the time of blood donation, 60 asymptomatic carriers, and 60 chronic hepatitis patients. The prevalence of genotype C was significantly higher in carriers with OBIs than in any other HBsAg-positive (HBsAg⁺) group (P < 0.001). Specific amino acid substitutions in the regions from amino acids 117 to 121 and amino acids 144 to 147 located in the major hydrophilic region of the S gene were associated with carriers with OBIs (P < 0.01 for carriers with OBIs versus HBsAg⁺ donors, carriers with OBIs versus HBsAg⁺ asymptomatic carriers, and carriers with OBIs versus HBsAg⁺ chronic hepatitis patients). G145R was the major variation in the HBV isolates responsible for local occult HBV infections.</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>19940057</pmid><doi>10.1128/JCM.01781-09</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Amino Acid Sequence Amino Acid Substitution Biological and medical sciences Blood Donors Carrier State - virology China DNA, Viral - genetics Female Fundamental and applied biological sciences. Psychology Genotype Hepatitis B - virology Hepatitis B Surface Antigens - genetics Hepatitis B virus Hepatitis B virus - genetics Hepatitis B virus - isolation & purification Hepatitis B, Chronic - virology Humans Male Microbiology Miscellaneous Molecular Sequence Data Mutation, Missense Sequence Analysis, DNA Virology Young Adult |
| title | Molecular Characteristics of Occult Hepatitis B Virus from Blood Donors in Southeast China |
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