Short-time cytotoxicity of mussel extracts: a new bioassay for okadaic acid detetion

Okadaic acid (OA), the main toxin responsible for diarrhoeic shellfish poisoning (DSP) has high cytotoxicity for KB cell cultures (apparent after 3 hr of contact), facilitating rapid detection in contaminated mussels. We developed a method to determine the minimal active concentration (MAC) based on...

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Veröffentlicht in:	Toxicon (Oxford) 1992, Vol.30 (11), p.1419-1425
Hauptverfasser:	Amzil, Z, Pouchus, Y.F, Boterff, J. le, Roussakis, C, Verbist, J.F, Marcaillou-Lebaut, C, Masselin, P
Format:	Artikel
Sprache:	eng
Schlagworte:	animal use alternatives bioassays carcinoma cell culture cell lines contamination cytotoxicity dinophyta epidermis humans mussels Mytilus edulis toxins
Online-Zugang:	Volltext
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