Involvement of the Toll-like receptor 4 pathway and use of TNF-α antagonists for treatment of the mucopolysaccharidoses

Enzyme replacement therapy is currently available for three of the mucopolysaccharidoses (MPSs) but has limited effects on the skeletal lesions. We investigated the involvement of the Toll-like receptor 4 (TLR4) signaling pathway in the pathogenesis of MPS bone and joint disease, and the use of the...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2010-01, Vol.107 (1), p.222-227
Hauptverfasser:	Simonaro, Calogera M, Ge, Yi, Eliyahu, Efrat, He, Xingxuan, Jepsen, Karl J, Schuchman, Edward H
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies Antibodies, Monoclonal - pharmacology Antibodies, Monoclonal - therapeutic use Antirheumatic Agents - pharmacology Antirheumatic Agents - therapeutic use Apoptosis Biological Sciences Bone and Bones - anatomy & histology Bone and Bones - diagnostic imaging Bone and Bones - metabolism Bone and Bones - pathology Bones Chondrocytes Disorders Epiphyses Humans Inflammation Infliximab Joint diseases Male Mice Mice, Knockout Mucopolysaccharidoses Mucopolysaccharidoses - drug therapy Mucopolysaccharidoses - immunology Mucopolysaccharidoses - pathology Rats Signal Transduction - drug effects Signal Transduction - immunology Toll-Like Receptor 4 - immunology Tumor Necrosis Factor-alpha - antagonists & inhibitors Tumor Necrosis Factor-alpha - immunology X-Ray Microtomography
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