Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

Identifying points of control in inflammation is essential to discovering safe and effective antiinflammatory medicines. Palmitoylethanolamide (PEA) is a naturally occurring lipid amide that, when administered as a drug, inhibits inflammatory responses by engaging peroxisome proliferator-activated r...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2009-12, Vol.106 (49), p.20966-20971
Hauptverfasser:	Solorzano, Carlos, Zhu, Chenggang, Battista, Natalia, Astarita, Giuseppe, Lodola, Alessio, Rivara, Silvia, Mor, Marco, Russo, Roberto, Maccarrone, Mauro, Antonietti, Francesca, Duranti, Andrea, Tontini, Andrea, Cuzzocrea, Salvatore, Tarzia, Giorgio, Piomelli, Daniele
Format:	Artikel
Sprache:	eng
Schlagworte:	Agonists Amides Amidohydrolases - antagonists & inhibitors Amidohydrolases - metabolism Animals Anti-Inflammatory Agents - pharmacology Antiinflammatories Biological Sciences Butyrates - pharmacology Carrageenan Catalytic Domain Cell Movement - drug effects Cells Drug Discovery Endocannabinoids Enzyme Inhibitors - pharmacology Ethanolamines Fatty acids Gene expression Inflammation Inflammation - enzymology Inflammation - pathology Leukocytes Lipids Mice Mice, Inbred C57BL Neutrophils - cytology Neutrophils - drug effects Neutrophils - enzymology Palmitic Acids - metabolism Peas Phenylpropionates - pharmacology Phenylurea Compounds - pharmacology PPAR alpha - agonists Proteins Rodents Spinal cord Spinal Cord Injuries - enzymology Spinal Cord Injuries - pathology Tissues Vehicles
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